SIRPG Antibody - #DF4508
| Product: | SIRPG Antibody |
| Catalog: | DF4508 |
| Description: | Rabbit polyclonal antibody to SIRPG |
| Application: | WB IF/ICC |
| Reactivity: | Human |
| Prediction: | Mouse |
| Mol.Wt.: | 42 KD; 42kD(Calculated). |
| Uniprot: | Q9P1W8 |
| RRID: | AB_2836859 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4508, RRID:AB_2836859.
Fold/Unfold
CD172 antigen like family member B; bA77C3.1; CD172 antigen-like family member B; CD172g; CD172g antigen; FLJ42230; RP11-77C3.2; Signal regulatory protein beta 2; Signal regulatory protein gamma; Signal-regulatory protein beta-2; Signal-regulatory protein gamma; SIRP B2; SIRP beta 2; SIRP gamma; SIRP-b2; SIRP-beta-2; SIRP-gamma; SIRPB2; SIRPG; SIRPG_HUMAN; SIRPgamma;
Immunogens
Detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. Mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection.
- Q9P1W8 SIRPG_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPVPASWPHPPGPFLLLTLLLGLTEVAGEEELQMIQPEKLLLVTVGKTATLHCTVTSLLPVGPVLWFRGVGPGRELIYNQKEGHFPRVTTVSDLTKRNNMDFSIRISSITPADVGTYYCVKFRKGSPENVEFKSGPGTEMALGAKPSAPVVLGPAARTTPEHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPTGQSVAYSIRSTARVVLDPWDVRSQVICEVAHVTLQGDPLRGTANLSEAIRVPPTLEVTQQPMRVGNQVNVTCQVRKFYPQSLQLTWSENGNVCQRETASTLTENKDGTYNWTSWFLVNISDQRDDVVLTCQVKHDGQLAVSKRLALEVTVHQKDQSSDATPGPASSLTALLLIAVLLGPIYVPWKQKT
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9P1W8 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K81 | Ubiquitination | Uniprot | |
| K96 | Ubiquitination | Uniprot | |
| K121 | Ubiquitination | Uniprot | |
| T138 | Phosphorylation | Uniprot | |
| S147 | Phosphorylation | Uniprot | |
| T158 | Phosphorylation | Uniprot | |
| T163 | Phosphorylation | Uniprot | |
| K181 | Ubiquitination | Uniprot | |
| S206 | Phosphorylation | Uniprot | |
| N243 | N-Glycosylation | Uniprot |
Research Backgrounds
Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.
Membrane>Single-pass type I membrane protein.
Detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. Mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection.
Interacts with CD47.
Research Fields
· Organismal Systems > Development > Osteoclast differentiation. (View pathway)
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