SH2D2A Antibody - #DF4497
| Product: | SH2D2A Antibody |
| Catalog: | DF4497 |
| Description: | Rabbit polyclonal antibody to SH2D2A |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human |
| Prediction: | Rabbit |
| Mol.Wt.: | 48 KD; 43kD(Calculated). |
| Uniprot: | Q9NP31 |
| RRID: | AB_2836848 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4497, RRID:AB_2836848.
Fold/Unfold
F2771; SCAP; SH2 domain containing adapter protein; SH2 domain containing protein 2A; SH2 domain protein 2A; SH2 domain-containing adapter protein; SH2 domain-containing protein 2A; SH22A_HUMAN; Sh2d2a; T cell specific adapter protein; T cell specific adapter protein TSAd; T cell specific adpater protein TSAd; T cell-specific adapter protein; T lymphocyte specific adaptor protein; TSAd; VEGF receptor associated protein; VEGF receptor-associated protein; VRAP;
Immunogens
Expression limited to tissues of the immune system and, in particular, activated T-cells. Expressed in peripheral blood leukocytes, thymus and spleen. Much lower expression or undetectable, in brain, placenta, skeletal muscle, prostate, testis, ovary, small intestine, and colon. Expressed at low levels in unstimulated T-cells, but not expressed in normal resting or activated B-cells. According to PubMed:10692392, expression is not restricted to activated T-cells, but strongly expressed in blood cell lineages, the endothelium and other cell and tissue types, such as heart, lung, and liver.
- Q9NP31 SH22A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEFPLAQICPQGSHEAPIPTFSTFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAEEVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRREAERLLEPKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQKEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQGPPLPHQPPPAWRHTLPHNLSRQVLQDRGQAWLPLGPPQ
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9NP31 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y39 | Phosphorylation | Uniprot | |
| S43 | Phosphorylation | Uniprot | |
| Y178 | Phosphorylation | Uniprot | |
| Y216 | Phosphorylation | Uniprot | |
| S217 | Phosphorylation | Uniprot | |
| K221 | Ubiquitination | Uniprot | |
| Y260 | Phosphorylation | P06239 (LCK) | Uniprot |
| T261 | Phosphorylation | Uniprot | |
| Y280 | Phosphorylation | P06239 (LCK) | Uniprot |
| Y290 | Phosphorylation | P06239 (LCK) | Uniprot |
| R294 | Methylation | Uniprot | |
| S296 | Phosphorylation | Uniprot | |
| S302 | Phosphorylation | Uniprot | |
| Y305 | Phosphorylation | P06239 (LCK) | Uniprot |
| S371 | Phosphorylation | Uniprot | |
| R378 | Methylation | Uniprot |
Research Backgrounds
Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation.
Phosphorylated on tyrosine residues.
Cytoplasm.
Expression limited to tissues of the immune system and, in particular, activated T-cells. Expressed in peripheral blood leukocytes, thymus and spleen. Much lower expression or undetectable, in brain, placenta, skeletal muscle, prostate, testis, ovary, small intestine, and colon. Expressed at low levels in unstimulated T-cells, but not expressed in normal resting or activated B-cells. According to expression is not restricted to activated T-cells, but strongly expressed in blood cell lineages, the endothelium and other cell and tissue types, such as heart, lung, and liver.
Interacts with KDR. Interacts with TXK and ITK (By similarity).
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