RGS1 Antibody - #DF4413
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| Product: | RGS1 Antibody |
| Catalog: | DF4413 |
| Description: | Rabbit polyclonal antibody to RGS1 |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 22 KD; 24kD(Calculated). |
| Uniprot: | Q08116 |
| RRID: | AB_2836768 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4413, RRID:AB_2836768.
Fold/Unfold
1R20; B cell activation protein BL34; B-cell activation protein BL34; BL34; Early response protein 1R20; IER 1; IER1; Immediate early response 1 B cell specific; immediate-early response 1, B-cell specific; IR20; Regulator of G protein signalling 1; Regulator of G-protein signaling 1; RGS 1; RGS1; RGS1_HUMAN;
Immunogens
Detected in peripheral blood monocytes (PubMed:10480894). Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high (PubMed:8473738).
- Q08116 RGS1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRAAAISTPKLDKMPGMFFSANPKELKGTTHSLLDDKMQKRRPKTFGMDMKAYLRSMIPHLESGMKSSKSKDVLSAAEVMQWSQSLEKLLANQTGQNVFGSFLKSEFSEENIEFWLACEDYKKTESDLLPCKAEEIYKAFVHSDAAKQINIDFRTRESTAKKIKAPTPTCFDEAQKVIYTLMEKDSYPRFLKSDIYLNLLNDLQANSLK
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q08116 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K13 | Methylation | Uniprot | |
| K24 | Methylation | Uniprot | |
| K66 | Ubiquitination | Uniprot | |
| S67 | Phosphorylation | Uniprot | |
| K69 | Ubiquitination | Uniprot | |
| K164 | Methylation | Uniprot |
Research Backgrounds
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.
Cell membrane>Peripheral membrane protein>Cytoplasmic side. Cytoplasm>Cytosol.
Detected in peripheral blood monocytes. Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high.
Interacts with GNAI1 and GNAQ.
References
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