KCNQ5 Antibody - #DF4322
| Product: | KCNQ5 Antibody |
| Catalog: | DF4322 |
| Description: | Rabbit polyclonal antibody to KCNQ5 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse |
| Prediction: | Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 100 KD; 102kD(Calculated). |
| Uniprot: | Q9NR82 |
| RRID: | AB_2836690 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4322, RRID:AB_2836690.
Fold/Unfold
KCNQ 5; KCNQ5; KCNQ5_HUMAN; KQT like 5; KQT-like 5; Kv7.5; OTTHUMP00000064152; OTTHUMP00000064153; Potassium channel alpha subunit KvLQT5; Potassium channel protein; Potassium channel subunit alpha KvLQT5; Potassium voltage gated channel KQT like subfamily member 5; Potassium voltage gated channel subfamily KQT member 5; Potassium voltage-gated channel subfamily KQT member 5; Voltage gated potassium channel subunit Kv7.5; Voltage-gated potassium channel subunit Kv7.5;
Immunogens
Strongly expressed in brain and skeletal muscle. In brain, expressed in cerebral cortex, occipital pole, frontal lobe and temporal lobe. Lower levels in hippocampus and putamen. Low to undetectable levels in medulla, cerebellum and thalamus.
- Q9NR82 KCNQ5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLLLGTRAATLGGGGGGLRESRRGKQGARMSLLGKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWKPHLKALHTCSPTKKEQGEASSSQKLSFKERVRMASPRGQSIKSRQASVGDRRSPSTDITAEGSPTKVQKSWSFNDRTRFRPSLRLKSSQPKPVIDADTALGTDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQILGKGQITSDKKSREKITAEHETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALALASFQIPPFECEQTSDYQSPVDSKDLSGSAQNSGCLSRSTSANISRGLQFILTPNEFSAQTFYALSPTMHSQATQVPISQSDGSAVAATNTIANQINTAPKPAAPTTLQIPPPLPAIKHLPRPETLHPNPAGLQESISDVTTCLVASKENVQVAQSNLTKDRSMRKSFDMGGETLLSVCPMVPKDLGKSLSVQNLIRSTEELNIQLSGSESSGSRGSQDFYPKWRESKLFITDEEVGPEETETDTFDAAPQPAREAAFASDSLRTGRSRSSQSICKAGESTDALSLPHVKLK
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9NR82 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T67 | Phosphorylation | Uniprot | |
| S78 | Phosphorylation | Uniprot | |
| S88 | Phosphorylation | Uniprot | |
| Y96 | Phosphorylation | Uniprot | |
| S263 | Phosphorylation | Uniprot | |
| S447 | Phosphorylation | Uniprot | |
| S457 | Phosphorylation | Uniprot | |
| T459 | Phosphorylation | Uniprot | |
| S464 | Phosphorylation | Uniprot | |
| S466 | Phosphorylation | Uniprot | |
| Y500 | Phosphorylation | Uniprot | |
| T581 | Phosphorylation | Uniprot | |
| S618 | Phosphorylation | Uniprot | |
| K619 | Ubiquitination | Uniprot | |
| Y657 | Phosphorylation | Uniprot | |
| S807 | Phosphorylation | Uniprot | |
| S831 | Phosphorylation | Uniprot | |
| Y861 | Phosphorylation | Uniprot | |
| K863 | Acetylation | Uniprot | |
| S902 | Phosphorylation | Uniprot |
Research Backgrounds
Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1.
Cell membrane>Multi-pass membrane protein.
Strongly expressed in brain and skeletal muscle. In brain, expressed in cerebral cortex, occipital pole, frontal lobe and temporal lobe. Lower levels in hippocampus and putamen. Low to undetectable levels in medulla, cerebellum and thalamus.
Heteromultimer with KCNQ3. Heterotetramer with KCNQ1; has a voltage-gated potassium channel activity.
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.5/KCNQ5 sub-subfamily.
Research Fields
· Organismal Systems > Nervous system > Cholinergic synapse.
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