SLC22A5 Antibody - #DF4269
| Product: | SLC22A5 Antibody |
| Catalog: | DF4269 |
| Description: | Rabbit polyclonal antibody to SLC22A5 |
| Application: | WB |
| Reactivity: | Human, Rat |
| Prediction: | Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 65 KD; 63kD(Calculated). |
| Uniprot: | O76082 |
| RRID: | AB_2836620 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4269, RRID:AB_2836620.
Fold/Unfold
CDSP; High-affinity sodium-dependent carnitine cotransporter; OCTN2; OCTN2VT; Organic cation/carnitine transporter 2; S22A5_HUMAN; Slc22a5; Solute carrier family 22 (organic cation/carnitine transporter) member 5; Solute carrier family 22 member 5;
Immunogens
Strongly expressed in kidney, skeletal muscle, heart and placenta. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells.
- O76082 S22A5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQERPTILKSTAF
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O76082 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N57 | N-Glycosylation | Uniprot | |
| T88 | Phosphorylation | Uniprot | |
| N91 | N-Glycosylation | Uniprot | |
| S93 | Phosphorylation | Uniprot | |
| K302 | Ubiquitination | Uniprot | |
| K324 | Ubiquitination | Uniprot | |
| T468 | Phosphorylation | Uniprot | |
| S470 | Phosphorylation | Uniprot | |
| S474 | Phosphorylation | Uniprot | |
| Y486 | Phosphorylation | Uniprot | |
| K543 | Ubiquitination | Uniprot | |
| T550 | Phosphorylation | Uniprot | |
| K553 | Ubiquitination | Uniprot |
Research Backgrounds
Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.
Membrane>Multi-pass membrane protein.
Strongly expressed in kidney, skeletal muscle, heart and placenta. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells.
Interacts with PDZK1.
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Research Fields
· Human Diseases > Cancers: Overview > Choline metabolism in cancer. (View pathway)
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