NUP107 Antibody - #DF4250

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Product: NUP107 Antibody
Catalog: DF4250
Description: Rabbit polyclonal antibody to NUP107
Application: WB IHC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
Mol.Wt.: 106 KD; 106kD(Calculated).
Uniprot: P57740
RRID: AB_2836601

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IHC 1:50-1:200, WB 1:500-1:1000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Zebrafish(80%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%), Xenopus(100%)
Clonality:
Polyclonal
Specificity:
NUP107 Antibody detects endogenous levels of total NUP107.
RRID:
AB_2836601
Cite Format: Affinity Biosciences Cat# DF4250, RRID:AB_2836601.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

107 kDa nucleoporin; NU107_HUMAN; Nuclear pore complex protein Nup107; Nucleoporin 107kDa; Nucleoporin Nup107; NUP107; NUP84; NUP84, yeast, homolog of; OTTHUMP00000240604; OTTHUMP00000240606;

Immunogens

Immunogen:
Uniprot:

P57740(NU107_HUMAN) >>Visit HPA database.

Gene(ID):
NUP107(57122)
Expression:
P57740 NU107_HUMAN:

Ubiquitously expressed in fetal and adult tissues.

Sequence:
MDRSGFGEISSPVIREAEVTRTARKQSAQKRVLLQASQDENFGNTTPRNQVIPRTPSSFRQPFTPTSRSLLRQPDISCILGTGGKSPRLTQSSGFFGNLSMVTNLDDSNWAAAFSSQRSGLFTNTEPHSITEDVTISAVMLREDDPGEAASMSMFSDFLQSFLKHSSSTVFDLVEEYENICGSQVNILSKIVSRATPGLQKFSKTASMLWLLQQEMVTWRLLASLYRDRIQSALEEESVFAVTAVNASEKTVVEALFQRDSLVRQSQLVVDWLESIAKDEIGEFSDNIEFYAKSVYWENTLHTLKQRQLTSYVGSVRPLVTELDPDAPIRQKMPLDDLDREDEVRLLKYLFTLIRAGMTEEAQRLCKRCGQAWRAATLEGWKLYHDPNVNGGTELEPVEGNPYRRIWKISCWRMAEDELFNRYERAIYAALSGNLKQLLPVCDTWEDTVWAYFRVMVDSLVEQEIQTSVATLDETEELPREYLGANWTLEKVFEELQATDKKRVLEENQEHYHIVQKFLILGDIDGLMDEFSKWLSKSRNNLPGHLLRFMTHLILFFRTLGLQTKEEVSIEVLKTYIQLLIREKHTNLIAFYTCHLPQDLAVAQYALFLESVTEFEQRHHCLELAKEADLDVATITKTVVENIRKKDNGEFSHHDLAPALDTGTTEEDRLKIDVIDWLVFDPAQRAEALKQGNAIMRKFLASKKHEAAKEVFVKIPQDSIAEIYNQCEEQGMESPLPAEDDNAIREHLCIRAYLEAHETFNEWFKHMNSVPQKPALIPQPTFTEKVAHEHKEKKYEMDFGIWKGHLDALTADVKEKMYNVLLFVDGGWMVDVREDAKEDHERTHQMVLLRKLCLPMLCFLLHTILHSTGQYQECLQLADMVSSERHKLYLVFSKEELRKLLQKLRESSLMLLDQGLDPLGYEIQL

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Chicken
100
Rabbit
100
Zebrafish
80
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P57740 As Substrate

Site PTM Type Enzyme
M1 Acetylation
S4 Phosphorylation
S10 Phosphorylation P24941 (CDK2)
S11 Phosphorylation P24941 (CDK2)
T22 Phosphorylation
K25 Methylation
S37 Phosphorylation
T45 Phosphorylation
T46 Phosphorylation
T55 Phosphorylation
S57 Phosphorylation
S58 Phosphorylation
R60 Methylation
T64 Phosphorylation
T66 Phosphorylation
S67 Phosphorylation
R68 Methylation
S69 Phosphorylation
S77 Phosphorylation
C78 S-Nitrosylation
T82 Phosphorylation
K85 Ubiquitination
S86 Phosphorylation
S119 Phosphorylation
S129 Phosphorylation
S153 Phosphorylation
S156 Phosphorylation
T196 Phosphorylation
K201 Ubiquitination
S232 Phosphorylation
T251 Phosphorylation
Y296 Phosphorylation
K305 Methylation
K305 Ubiquitination
S315 Phosphorylation
T321 Phosphorylation
K332 Ubiquitination
K348 Ubiquitination
K382 Ubiquitination
K408 Ubiquitination
K491 Ubiquitination
K501 Ubiquitination
K502 Ubiquitination
Y512 Phosphorylation
S569 Phosphorylation
K626 Ubiquitination
K637 Ubiquitination
K646 Ubiquitination
K690 Ubiquitination
S702 Phosphorylation
K709 Acetylation
K709 Ubiquitination
K714 Acetylation
K773 Ubiquitination
K785 Ubiquitination
K803 Ubiquitination
K814 Ubiquitination
K816 Ubiquitination
K837 Ubiquitination

Research Backgrounds

Function:

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC. Involved in nephrogenesis.

Subcellular Location:

Nucleus membrane. Nucleus>Nuclear pore complex. Chromosome>Centromere>Kinetochore.
Note: Located on both the cytoplasmic and nuclear sides of the NPC core structure (PubMed:11564755). During mitosis, localizes to the kinetochores (PubMed:11564755). Dissociates from the dissasembled NPC structure late during prophase of mitosis (PubMed:11564755).

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Ubiquitously expressed in fetal and adult tissues.

Subunit Structure:

Part of the nuclear pore complex (NPC). Forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and Nup96; this complex plays a role in RNA export and in tethering Nup98 and NUP153 to the nucleus. Does not interact with TPR. Interacts with ZNF106 (By similarity).

Family&Domains:

Belongs to the nucleoporin Nup84/Nup107 family.

Research Fields

· Genetic Information Processing > Translation > RNA transport.

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