NCR1 Antibody - #DF4220

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Product: NCR1 Antibody
Catalog: DF4220
Description: Rabbit polyclonal antibody to NCR1
Application: WB IF/ICC
Reactivity: Human
Mol.Wt.: 40 KD; 34kD(Calculated).
Uniprot: O76036
RRID: AB_2836571

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
NCR1 Antibody detects endogenous levels of total NCR1.
RRID:
AB_2836571
Cite Format: Affinity Biosciences Cat# DF4220, RRID:AB_2836571.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Activating NK receptor NK p46; CD335; FLJ99094; hNKp46; Ly94; Lymphocyte antigen 94; Lymphocyte antigen 94 homolog (activating NK receptor; NK p46); Lymphocyte antigen 94 homolog; Natural cytotoxicity triggering receptor 1; Natural killer cell p46-related protein; NCR1; NCT1; NCTR1_HUMAN; NK cell activating receptor; NK cell-activating receptor; NK-p46; NKp46;

Immunogens

Immunogen:
Uniprot:

O76036(NCTR1_HUMAN) >>Visit HPA database.

Gene(ID):
NCR1(9437)
Expression:
O76036 NCTR1_HUMAN:

Selectively expressed by both resting and activated NK cells.

Sequence:
MSSTLPALLCVGLCLSQRISAQQQTLPKPFIWAEPHFMVPKEKQVTICCQGNYGAVEYQLHFEGSLFAVDRPKPPERINKVKFYIPDMNSRMAGQYSCIYRVGELWSEPSNLLDLVVTEMYDTPTLSVHPGPEVISGEKVTFYCRLDTATSMFLLLKEGRSSHVQRGYGKVQAEFPLGPVTTAHRGTYRCFGSYNNHAWSFPSEPVKLLVTGDIENTSLAPEDPTFPADTWGTYLLTTETGLQKDHALWDHTAQNLLRMGLAFLVLVALVWFLVEDWLSRKRTRERASRASTWEGRRRLNTQTL

PTMs - O76036 As Substrate

Site PTM Type Enzyme
Y84 Phosphorylation
S90 Phosphorylation
T292 Phosphorylation

Research Backgrounds

Function:

Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

PTMs:

N-glycosylated.

O-glycosylated.

Subcellular Location:

Cell membrane>Single-pass type I membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Selectively expressed by both resting and activated NK cells.

Subunit Structure:

Interacts with CD247 and FCER1G.

Family&Domains:

Belongs to the natural cytotoxicity receptor (NCR) family.

Research Fields

· Organismal Systems > Immune system > Natural killer cell mediated cytotoxicity.   (View pathway)

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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