Product: MAZ Antibody
Catalog: DF4190
Description: Rabbit polyclonal antibody to MAZ
Application: WB
Reactivity: Human, Mouse, Rat
Prediction: Pig
Mol.Wt.: 48 KD; 49kD(Calculated).
Uniprot: P56270
RRID: AB_2836555

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Product Info

Source:
Rabbit
Application:
WB 1:500-1:1000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%)
Clonality:
Polyclonal
Specificity:
MAZ Antibody detects endogenous levels of total MAZ.
RRID:
AB_2836555
Cite Format: Affinity Biosciences Cat# DF4190, RRID:AB_2836555.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

MAZ; MAZ_HUMAN; MAZI; MYC associated zinc finger protein; Myc-associated zinc finger protein; Pur-1; Pur1; Purine binding transcription factor; Purine-binding transcription factor; SAF 1; SAF 2; SAF-1; SAF-2; SAF-3; Serum amyloid A activating factor 1; Serum amyloid A activating factor 2; Transcription factor Zif87; ZF87; Zif87; Zinc finger protein 801; Zinc finger protein, 87 kilodaltons; ZNF801;

Immunogens

Immunogen:
Uniprot:
Gene(ID):
Expression:
P56270 MAZ_HUMAN:

Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and midfrontal cortex (at protein level).

Sequence:
MFPVFPCTLLAPPFPVLGLDSRGVGGLMNSFPPPQGHAQNPLQVGAELQSRFFASQGCAQSPFQAAPAPPPTPQAPAAEPLQVDLLPVLAAAQESAAAAAAAAAAAAAVAAAPPAPAAASTVDTAALKQPPAPPPPPPPVSAPAAEAAPPASAATIAAAAATAVVAPTSTVAVAPVASALEKKTKSKGPYICALCAKEFKNGYNLRRHEAIHTGAKAGRVPSGAMKMPTMVPLSLLSVPQLSGAGGGGGEAGAGGGAAAVAAGGVVTTTASGKRIRKNHACEMCGKAFRDVYHLNRHKLSHSDEKPYQCPVCQQRFKRKDRMSYHVRSHDGAVHKPYNCSHCGKSFSRPDHLNSHVRQVHSTERPFKCEKCEAAFATKDRLRAHTVRHEEKVPCHVCGKMLSSAYISDHMKVHSQGPHHVCELCNKGTGEVCPMAAAAAAAAAAAAAAVAAPPTAVGSLSGAEGVPVSSQPLPSQPW

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
0
Bovine
0
Sheep
0
Dog
0
Xenopus
0
Zebrafish
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P56270 As Substrate

Site PTM Type Enzyme
T72 Phosphorylation P27361 (MAPK3)
S186 Phosphorylation P17612 (PRKACA)
T213 Phosphorylation
K216 Ubiquitination
S222 Phosphorylation
S237 Phosphorylation
K273 Acetylation
K286 Ubiquitination
K298 Ubiquitination
S300 Phosphorylation
S302 Phosphorylation
K305 Ubiquitination
Y307 Phosphorylation
R321 Methylation
S323 Phosphorylation
Y324 Phosphorylation
R357 Methylation
S361 Phosphorylation
K378 Acetylation
K378 Ubiquitination
T385 Phosphorylation P31749 (AKT1) , P17612 (PRKACA)
S414 Phosphorylation
S460 Phosphorylation P68400 (CSNK2A1)
S469 Phosphorylation
S474 Phosphorylation

Research Backgrounds

Function:

May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins.

Subcellular Location:

Nucleus.
Note: In brains of Alzheimer disease patients, present in a plaque-like structures.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and midfrontal cortex (at protein level).

Subunit Structure:

Interacts with BPTF.

Restrictive clause

 

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For Research Use Only.
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