ACSL6 Antibody - #DF4142
| Product: | ACSL6 Antibody |
| Catalog: | DF4142 |
| Description: | Rabbit polyclonal antibody to ACSL6 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 78 KD; 78kD(Calculated). |
| Uniprot: | Q9UKU0 |
| RRID: | AB_2836507 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4142, RRID:AB_2836507.
Fold/Unfold
ACS2; Acyl CoA synthetase long chain family member 6; FACL6; Fatty acid Coenzyme A ligase, long chain 6; LACS 6; LACS2; LACS5; Long chain acyl CoA synthetase 6; Long chain fatty acid CoA ligase 6; Long fatty acyl CoA synthetase 2;
Immunogens
Expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derived from fetal liver, hemopoietic stem cells from cord blood, bone marrow and brain.
- Q9UKU0 ACSL6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MQTQEILRILRLPELGDLGQFFRSLSATTLVSMGALAAILAYWFTHRPKALQPPCNLLMQSEEVEDSGGARRSVIGSGPQLLTHYYDDARTMYQVFRRGLSISGNGPCLGFRKPKQPYQWLSYQEVADRAEFLGSGLLQHNCKACTDQFIGVFAQNRPEWIIVELACYTYSMVVVPLYDTLGPGAIRYIINTADISTVIVDKPQKAVLLLEHVERKETPGLKLIILMDPFEEALKERGQKCGVVIKSMQAVEDCGQENHQAPVPPQPDDLSIVCFTSGTTGNPKGAMLTHGNVVADFSGFLKVTEKVIFPRQDDVLISFLPLAHMFERVIQSVVYCHGGRVGFFQGDIRLLSDDMKALCPTIFPVVPRLLNRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLPAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLHSFEQVKAIHIHSDMFSVQNGLLTPTLKAKRPELREYFKKQIEELYSISM
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UKU0 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K143 | Acetylation | Uniprot | |
| T192 | Phosphorylation | Uniprot | |
| S196 | Phosphorylation | Uniprot | |
| T197 | Phosphorylation | Uniprot | |
| K356 | Ubiquitination | Uniprot | |
| S379 | Phosphorylation | Uniprot | |
| K395 | Ubiquitination | Uniprot | |
| T549 | Phosphorylation | Uniprot | |
| K551 | Ubiquitination | Uniprot | |
| Y621 | Phosphorylation | Uniprot | |
| K643 | Ubiquitination | Uniprot |
Research Backgrounds
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid.
Mitochondrion outer membrane>Single-pass type III membrane protein. Peroxisome membrane>Single-pass type III membrane protein. Microsome membrane>Single-pass type III membrane protein. Endoplasmic reticulum membrane>Single-pass type III membrane protein.
Expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derived from fetal liver, hemopoietic stem cells from cord blood, bone marrow and brain.
Belongs to the ATP-dependent AMP-binding enzyme family.
Research Fields
· Cellular Processes > Transport and catabolism > Peroxisome. (View pathway)
· Cellular Processes > Cell growth and death > Ferroptosis. (View pathway)
· Metabolism > Lipid metabolism > Fatty acid biosynthesis.
· Metabolism > Lipid metabolism > Fatty acid degradation.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Fatty acid metabolism.
· Organismal Systems > Endocrine system > PPAR signaling pathway.
· Organismal Systems > Endocrine system > Adipocytokine signaling pathway.
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