GIMAP4 Antibody - #DF4101

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Product: GIMAP4 Antibody
Catalog: DF4101
Description: Rabbit polyclonal antibody to GIMAP4
Application: WB IF/ICC
Reactivity: Human, Mouse
Prediction: Dog
Mol.Wt.: 38 KD; 38kD(Calculated).
Uniprot: Q9NUV9
RRID: AB_2836475

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Prediction:
Dog(88%)
Clonality:
Polyclonal
Specificity:
GIMAP4 Antibody detects endogenous levels of total GIMAP4.
RRID:
AB_2836475
Cite Format: Affinity Biosciences Cat# DF4101, RRID:AB_2836475.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

FLJ11110; GIMA4_HUMAN; Gimap4; GTPase IMAP family member 4; GTPase IMAP family member 4; hIAN1; HIMAP4; Human immune associated nucleotide 1; IAN-1; IAN1; IMAP4; Immunity associated nucleotide 1 protein; Immunity associated protein 4; Immunity-associated nucleotide 1 protein; Immunity-associated protein 4; MSTP062;

Immunogens

Immunogen:
Uniprot:

Q9NUV9(GIMA4_HUMAN) >>Visit HPA database.

Gene(ID):
GIMAP4(55303)
Expression:
Q9NUV9 GIMA4_HUMAN:

Highly expressed in spleen and peripheral blood leukocytes that contain mostly T- and B-lymphocytes. Expressed specifically in resting T- and B-lymphocytes and expression significantly decreases during B- or T-lymphocyte activation. Expressed at lower levels in thymus, ovary, colon and small intestine.

Sequence:
MAAQYGSMSFNPSTPGASYGPGRQEPRNSQLRIVLVGKTGAGKSATGNSILGRKVFHSGTAAKSITKKCEKRSSSWKETELVVVDTPGIFDTEVPNAETSKEIIRCILLTSPGPHALLLVVPLGRYTEEEHKATEKILKMFGERARSFMILIFTRKDDLGDTNLHDYLREAPEDIQDLMDIFGDRYCALNNKATGAEQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYAVRQQRARTEVESKDGILELIMTALQIASFILLRLFAED

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Dog
88
Bovine
75
Pig
73
Horse
0
Sheep
0
Xenopus
0
Zebrafish
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9NUV9 As Substrate

Site PTM Type Enzyme
S7 Phosphorylation
Y19 Phosphorylation
K38 Ubiquitination
T39 Phosphorylation
K43 Ubiquitination
K54 Ubiquitination
S58 Phosphorylation
K63 Ubiquitination
K67 Acetylation
K71 Acetylation
K77 Ubiquitination
T134 Phosphorylation
K192 Ubiquitination
K217 Ubiquitination
Y226 Phosphorylation
K235 Ubiquitination
T237 Phosphorylation
K252 Ubiquitination
Y259 Phosphorylation
K262 Acetylation
K262 Ubiquitination
K269 Acetylation
K282 Ubiquitination
Y290 Phosphorylation

Research Backgrounds

Function:

During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP.

PTMs:

Phosphorylated at very low levels in resting splenocytes. Rapidly and transiently phosphorylated in response to splenocyte activation.

Subcellular Location:

Cytoplasm>Cytosol.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Highly expressed in spleen and peripheral blood leukocytes that contain mostly T- and B-lymphocytes. Expressed specifically in resting T- and B-lymphocytes and expression significantly decreases during B- or T-lymphocyte activation. Expressed at lower levels in thymus, ovary, colon and small intestine.

Subunit Structure:

May interact (via IQ domain) with calmodulin/CALM1 only in the absence of Ca(2+) (By similarity). Interacts with BAX, but not with other Bcl-2 family members (By similarity).

Family&Domains:

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

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