Claudin 6 Antibody - #DF3946
| Product: | Claudin 6 Antibody |
| Catalog: | DF3946 |
| Description: | Rabbit polyclonal antibody to Claudin 6 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse |
| Prediction: | Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 26 KD; 23kD(Calculated). |
| Uniprot: | P56747 |
| RRID: | AB_2836299 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF3946, RRID:AB_2836299.
Fold/Unfold
Claudin-6; Claudin6; CLD6_HUMAN; CLDN 6; CLDN6; OTTHUMP00000159248; Skullin 2; Skullin; UNQ757/PRO1488;
Immunogens
Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.
- P56747 CLD6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASAGMQILGVVLTLLGWVNGLVSCALPMWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVIALLVALFGLLVYLAGAKCTTCVEEKDSKARLVLTSGIVFVISGVLTLIPVCWTAHAIIRDFYNPLVAEAQKRELGASLYLGWAASGLLLLGGGLLCCTCPSGGSQGPSHYMARYSTSAPAISRGPSEYPTKNYV
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P56747 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y200 | Phosphorylation | Uniprot | |
| S201 | Phosphorylation | Uniprot | |
| T202 | Phosphorylation | Uniprot | |
| S203 | Phosphorylation | Uniprot | |
| S208 | Phosphorylation | Uniprot | |
| S212 | Phosphorylation | Uniprot | |
| Y214 | Phosphorylation | Uniprot | |
| T216 | Phosphorylation | Uniprot | |
| K217 | Ubiquitination | Uniprot | |
| Y219 | Phosphorylation | Uniprot |
Research Backgrounds
Plays a major role in tight junction-specific obliteration of the intercellular space.
(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.
Cell junction>Tight junction. Cell membrane>Multi-pass membrane protein.
Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.
Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). Interacts with CLDN1, CD81 and OCLN.
Belongs to the claudin family.
Research Fields
· Cellular Processes > Cellular community - eukaryotes > Tight junction. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)
· Human Diseases > Infectious diseases: Viral > Hepatitis C.
· Organismal Systems > Immune system > Leukocyte transendothelial migration. (View pathway)
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