APOL1 Antibody - #DF3785

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Product: APOL1 Antibody
Catalog: DF3785
Description: Rabbit polyclonal antibody to APOL1
Application: WB IHC IF/ICC
Reactivity: Human
Mol.Wt.: 44 KD; 44kD(Calculated).
Uniprot: O14791
RRID: AB_2836142

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
APOL1 Antibody detects endogenous levels of total APOL1.
RRID:
AB_2836142
Cite Format: Affinity Biosciences Cat# DF3785, RRID:AB_2836142.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

APO L; Apo-L; ApoL; APOL I; ApoL-I; APOL1; APOL1_HUMAN; APOLI; Apolipoprotein L; Apolipoprotein L I; Apolipoprotein L-I; Apolipoprotein L1; FSGS4;

Immunogens

Immunogen:
Uniprot:

O14791(APOL1_HUMAN) >>Visit HPA database.

Gene(ID):
APOL1(8542)
Expression:
O14791 APOL1_HUMAN:

Plasma. Found on APOA-I-containing high density lipoprotein (HDL3). Expressed in pancreas, lung, prostate, liver, placenta and spleen.

Sequence:
MEGAALLRVSVLCIWMSALFLGVGVRAEEAGARVQQNVPSGTDTGDPQSKPLGDWAAGTMDPESSIFIEDAIKYFKEKVSTQNLLLLLTDNEAWNGFVAAAELPRNEADELRKALDNLARQMIMKDKNWHDKGQQYRNWFLKEFPRLKSELEDNIRRLRALADGVQKVHKGTTIANVVSGSLSISSGILTLVGMGLAPFTEGGSLVLLEPGMELGITAALTGITSSTMDYGKKWWTQAQAHDLVIKSLDKLKEVREFLGENISNFLSLAGNTYQLTRGIGKDIRALRRARANLQSVPHASASRPRVTEPISAESGEQVERVNEPSILEMSRGVKLTDVAPVSFFLVLDVVYLVYESKHLHEGAKSETAEELKKVAQELEEKLNILNNNYKILQADQEL

PTMs - O14791 As Substrate

Site PTM Type Enzyme
K148 Ubiquitination
T236 O-Glycosylation
N261 N-Glycosylation
T307 Phosphorylation
S311 Phosphorylation
S314 Phosphorylation

Research Backgrounds

Function:

May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.

PTMs:

Phosphorylated by FAM20C in the extracellular medium.

Subcellular Location:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Plasma. Found on APOA-I-containing high density lipoprotein (HDL3). Expressed in pancreas, lung, prostate, liver, placenta and spleen.

Subunit Structure:

In plasma, interacts with APOA1 and mainly associated with large high density lipoprotein particles.

Family&Domains:

Belongs to the apolipoprotein L family.

Research Fields

· Human Diseases > Infectious diseases: Parasitic > African trypanosomiasis.

Restrictive clause

 

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