LPCAT2 Antibody - #DF3738
| Product: | LPCAT2 Antibody |
| Catalog: | DF3738 |
| Description: | Rabbit polyclonal antibody to LPCAT2 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Sheep, Rabbit, Dog, Chicken |
| Mol.Wt.: | 50 KD; 60kD(Calculated). |
| Uniprot: | Q7L5N7 |
| RRID: | AB_2836102 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF3738, RRID:AB_2836102.
Fold/Unfold
1 acylglycerophosphocholine O acyltransferase; 1 alkylglycerophosphocholine O acetyltransferase; 1-acylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase; A330042H22; Acetyl CoA:lyso PAF acetyltransferase; Acetyl-CoA:lyso-PAF acetyltransferase; Acetyl-CoA:lyso-platelet-activating factor acetyltransferase; acyl CoA:lysophosphatidylcholine acyltransferase 2; Acyl-CoA:lysophosphatidylcholine acyltransferase member 1; Acyltransferase like 1A; Acyltransferase-like 1; AYTL1; Aytl1a; DKFZp686H22112; FLJ20481; lpafat1; LPC acyltransferase 2; LPCAT-2; LPCAT2; Lyso PAF acetyltransferase; Lyso platelet activating factor (PAF) acetyltransferase; Lyso-PAF acetyltransferase; LysoPAFAT; LysoPAFAT/LPCAT2; LysoPC acyltransferase 2; Lysophosphatidylcholine acyltransferase 2; OTTMUSP00000029641; PCAT2_HUMAN; RGD1563994;
Immunogens
- Q7L5N7 PCAT2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSRCAQAAEVAATVPGAGVGNVGLRPPMVPRQASFFPPPVPNPFVQQTQIGSARRVQIVLLGIILLPIRVLLVALILLLAWPFAAISTVCCPEKLTHPITGWRRKITQTALKFLGRAMFFSMGFIVAVKGKIASPLEAPVFVAAPHSTFFDGIACVVAGLPSMVSRNENAQVPLIGRLLRAVQPVLVSRVDPDSRKNTINEIIKRTTSGGEWPQILVFPEGTCTNRSCLITFKPGAFIPGVPVQPVLLRYPNKLDTVTWTWQGYTFIQLCMLTFCQLFTKVEVEFMPVQVPNDEEKNDPVLFANKVRNLMAEALGIPVTDHTYEDCRLMISAGQLTLPMEAGLVEFTKISRKLKLDWDGVRKHLDEYASIASSSKGGRIGIEEFAKYLKLPVSDVLRQLFALFDRNHDGSIDFREYVIGLAVLCNPSNTEEIIQVAFKLFDVDEDGYITEEEFSTILQASLGVPDLDVSGLFKEIAQGDSISYEEFKSFALKHPEYAKIFTTYLDLQTCHVFSLPKEVQTTPSTASNKVSPEKHEESTSDKKDD
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q7L5N7 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T13 | Phosphorylation | Uniprot | |
| S34 | Phosphorylation | P49137 (MAPKAPK2) | Uniprot |
| K105 | Ubiquitination | Uniprot | |
| S121 | Phosphorylation | Uniprot | |
| K204 | Acetylation | Uniprot | |
| K204 | Ubiquitination | Uniprot | |
| Y250 | Phosphorylation | Uniprot | |
| K362 | Ubiquitination | Uniprot | |
| Y367 | Phosphorylation | Uniprot | |
| K375 | Ubiquitination | Uniprot | |
| K386 | Ubiquitination | Uniprot | |
| K389 | Ubiquitination | Uniprot | |
| S482 | Phosphorylation | Uniprot | |
| Y483 | Phosphorylation | Uniprot | |
| K487 | Ubiquitination | Uniprot | |
| T521 | Phosphorylation | Uniprot | |
| S526 | Phosphorylation | Uniprot | |
| K528 | Ubiquitination | Uniprot | |
| S530 | Phosphorylation | Uniprot | |
| S539 | Phosphorylation | Uniprot |
Research Backgrounds
Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3-phosphocholine.
Endoplasmic reticulum membrane>Single-pass type II membrane protein. Golgi apparatus membrane>Single-pass type II membrane protein. Lipid droplet.
The HXXXXD motif is essential for acyltransferase activity.
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Research Fields
· Metabolism > Lipid metabolism > Glycerophospholipid metabolism.
· Metabolism > Lipid metabolism > Ether lipid metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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