BCL10 Antibody - #DF3606
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF3606, RRID:AB_2835978.
Fold/Unfold
AI132454; B cell CLL/lymphoma 10; B cell lymphoma/leukemia10; B-cell CLL/lymphoma 10; B-cell leukemia/lymphoma 10; B-cell lymphoma/leukemia 10; Bcl 10; Bcl-10; Bcl10; BCL10_HUMAN; c E10; c-E10; C81403; CARD containing apoptotic signaling protein; CARD containing molecule enhancing NF kappa B; CARD containing molecule enhancing NF kB; CARD containing molecule enhancing NF-kB; CARD containing molecule enhancing NFkB; CARD containing proapoptotic protein; CARD like apoptotic protein; CARD-containing apoptotic signaling protein; CARD-containing molecule enhancing NF-kappa-B; CARD-containing proapoptotic protein; CARD-like apoptotic protein; CARMEN; Caspase recruiting domain containing protein; caspase-recruiting domain-containing protein; cCARMEN; cE 10; cE10; CED 3/ICH 1 prodomain homologous E10 like regulator; CED-3/ICH-1 prodomain homologous E10-like regulator; CED3/ICH1 prodomain homologous E10 like regulator; Cellular E10; Cellular homolog of vCARMEN; Cellular-E10; CIPER; CLAP; hCLAP; Mammalian CARD containing adapter molecule E10; Mammalian CARD-containing adapter molecule E10; mE 10; mE10; R-RCD1;
Immunogens
- O95999 BCL10_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEPTAPSLTEEDLTEVKKDALENLRVYLCEKIIAERHFDHLRAKKILSREDTEEISCRTSSRKRAGKLLDYLQENPKGLDTLVESIRREKTQNFLIQKITDEVLKLRNIKLEHLKGLKCSSCEPFPDGATNNLSRSNSDESNFSEKLRASTVMYHPEGESSTTPFFSTNSSLNLPVLEVGRTENTIFSSTTLPRPGDPGAPPLPPDLQLEEEGTCANSSEMFLPLRSRTVSRQ
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O95999 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Phosphorylation | Uniprot | ||
| M1 | Acetylation | Uniprot | |
| T4 | Phosphorylation | Uniprot | |
| K17 | Ubiquitination | Uniprot | |
| K18 | Ubiquitination | Uniprot | |
| K31 | Ubiquitination | Uniprot | |
| T52 | Phosphorylation | Uniprot | |
| K63 | Ubiquitination | Uniprot | |
| K67 | Ubiquitination | Uniprot | |
| K77 | Ubiquitination | Uniprot | |
| S85 | Phosphorylation | Uniprot | |
| K90 | Ubiquitination | Uniprot | |
| T91 | Phosphorylation | Uniprot | |
| K98 | Ubiquitination | Uniprot | |
| T100 | Phosphorylation | Uniprot | |
| K105 | Ubiquitination | Uniprot | |
| K110 | Ubiquitination | Uniprot | |
| K115 | Ubiquitination | Uniprot | |
| K118 | Ubiquitination | Uniprot | |
| T130 | Phosphorylation | Uniprot | |
| S134 | Phosphorylation | O14920 (IKBKB) | Uniprot |
| S136 | Phosphorylation | Uniprot | |
| S138 | Phosphorylation | Q9UQM7 (CAMK2A) | Uniprot |
| S141 | Phosphorylation | Uniprot | |
| S144 | Phosphorylation | Uniprot | |
| K146 | Ubiquitination | Uniprot | |
| T163 | Phosphorylation | Uniprot | |
| S170 | Phosphorylation | Uniprot | |
| S171 | Phosphorylation | Uniprot | |
| S218 | Phosphorylation | P31749 (AKT1) | Uniprot |
| S227 | Phosphorylation | Uniprot | |
| T229 | Phosphorylation | Uniprot | |
| S231 | Phosphorylation | P31749 (AKT1) | Uniprot |
Research Backgrounds
Involved in adaptive immune response. Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.
Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2. Phosphorylated by IKBKB/IKKB.
Cytoplasm>Perinuclear region. Membrane raft.
Note: Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts.
Ubiquitous.
Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Self-associates by CARD-CARD interaction and forms a tight complex with MALT1. Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Forms a complex with CARD14 and MALT1; resulting in the formation of a CBM (CARD14-BCL10-MALT1) complex. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2. Interacts with PELI2 and SOCS3; these interactions may be mutually exclusive (By similarity). Interacts with CARD11 and MALT1; as part of a CBM (CARD11-BCL10-MALT1) complex involved in NF-kappa-B activation.
Research Fields
· Environmental Information Processing > Signal transduction > NF-kappa B signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Tuberculosis.
· Organismal Systems > Immune system > T cell receptor signaling pathway. (View pathway)
· Organismal Systems > Immune system > B cell receptor signaling pathway. (View pathway)
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