5HT6 Receptor Antibody - #DF3505
| Product: | 5HT6 Receptor Antibody |
| Catalog: | DF3505 |
| Description: | Rabbit polyclonal antibody to 5HT6 Receptor |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Dog |
| Mol.Wt.: | 47 KD; 47kD(Calculated). |
| Uniprot: | P50406 |
| RRID: | AB_2835867 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF3505, RRID:AB_2835867.
Fold/Unfold
5 HT 6; 5 HT6; 5 HT6R; 5 hydroxytryptamine (serotonin) receptor 6 G protein coupled; 5 hydroxytryptamine 6 receptor; 5 hydroxytryptamine receptor 6; 5-HT-6; 5-HT6; 5-hydroxytryptamine receptor 6; 5HT 6; 5HT6R_HUMAN; HTR 6; Htr6; Serotonin receptor 6;
Immunogens
Expressed in several human brain regions, most prominently in the caudate nucleus.
- P50406 5HT6R_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P50406 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y125 | Phosphorylation | Uniprot | |
| K258 | Methylation | Uniprot | |
| K262 | Methylation | Uniprot | |
| S347 | Phosphorylation | Uniprot |
Research Backgrounds
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling.
Cell membrane>Multi-pass membrane protein.
Expressed in several human brain regions, most prominently in the caudate nucleus.
Interacts with MTOR, RPTOR and NF1. Interacts with CDK5 (By similarity).
Belongs to the G-protein coupled receptor 1 family.
Research Fields
· Environmental Information Processing > Signal transduction > Calcium signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cAMP signaling pathway. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
· Organismal Systems > Nervous system > Serotonergic synapse.
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