SLK Antibody - #DF3431

(3)  
Product: SLK Antibody
Catalog: DF3431
Description: Rabbit polyclonal antibody to SLK
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
Mol.Wt.: 150 KD; 143kD(Calculated).
Uniprot: Q9H2G2
RRID: AB_2835731

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 100ul $280 In stock
 200ul $350 In stock

Lead Time: Same day delivery

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:1000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%), Xenopus(100%)
Clonality:
Polyclonal
Specificity:
SLK Antibody detects endogenous levels of total SLK.
RRID:
AB_2835731
Cite Format: Affinity Biosciences Cat# DF3431, RRID:AB_2835731.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

CTCL tumor antigen se20 9; LOSK; se20 9; Serine/threonine protein kinase 2; SLK; SNF1 sucrose nonfermenting like kinase; STE20 like serine/threonine-protein kinase; STE20 related kinase; STK2;

Immunogens

Immunogen:
Uniprot:

Q9H2G2(SLK_HUMAN) >>Visit HPA database.

Gene(ID):
SLK(9748)
Expression:
Q9H2G2 SLK_HUMAN:

Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle.

Sequence:
MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEVPIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADTDQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSGENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSTQSRISKFYPIPSLHSTGS

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Chicken
100
Rabbit
100
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9H2G2 As Substrate

Site PTM Type Enzyme
S2 Phosphorylation
K11 Ubiquitination
S14 Phosphorylation
Y21 Phosphorylation
K50 Ubiquitination
K54 Ubiquitination
T56 Phosphorylation
S57 Phosphorylation
K63 Ubiquitination
T139 Phosphorylation
K150 Ubiquitination
S177 Phosphorylation
K179 Ubiquitination
T181 Phosphorylation
T183 Phosphorylation
S189 Phosphorylation
T193 Phosphorylation
Y195 Phosphorylation
Y212 Phosphorylation
Y214 Phosphorylation
K249 Ubiquitination
S250 Phosphorylation
T254 Phosphorylation
K266 Ubiquitination
K298 Ubiquitination
K319 Ubiquitination
T327 Phosphorylation
S330 Phosphorylation
S336 Phosphorylation
K337 Ubiquitination
S340 Phosphorylation
S341 Phosphorylation
S344 Phosphorylation
S347 Phosphorylation P68400 (CSNK2A1)
S348 Phosphorylation P68400 (CSNK2A1)
S354 Phosphorylation
C358 S-Nitrosylation
S362 Phosphorylation
K366 Ubiquitination
S370 Phosphorylation
S372 Phosphorylation
K384 Ubiquitination
R415 Methylation
S446 Phosphorylation
S448 Phosphorylation
K492 Ubiquitination
T494 Phosphorylation
T506 Phosphorylation
S518 Phosphorylation
K524 Ubiquitination
T545 Phosphorylation
S546 Phosphorylation
T551 Phosphorylation
S565 Phosphorylation
T569 Phosphorylation
S571 Phosphorylation
K583 Ubiquitination
K587 Ubiquitination
S646 Phosphorylation
S655 Phosphorylation
K663 Ubiquitination
S667 Phosphorylation
S728 Phosphorylation
S730 Phosphorylation
T755 Phosphorylation
S772 Phosphorylation
T774 Phosphorylation
K775 Methylation
K775 Ubiquitination
S777 Phosphorylation
S779 Phosphorylation
S781 Phosphorylation
T785 Phosphorylation
T814 Phosphorylation
S816 Phosphorylation
S818 Phosphorylation
T820 Phosphorylation
K839 Ubiquitination
S850 Phosphorylation
K851 Ubiquitination
K917 Ubiquitination
K1024 Ubiquitination
Y1052 Phosphorylation
S1089 Phosphorylation
S1094 Phosphorylation
T1097 Phosphorylation
K1106 Ubiquitination
K1114 Ubiquitination
C1153 S-Nitrosylation
K1187 Ubiquitination
T1188 Phosphorylation
K1196 Ubiquitination
K1205 Methylation
C1212 S-Nitrosylation
S1219 Phosphorylation
Y1225 Phosphorylation
S1229 Phosphorylation
S1235 Phosphorylation

PTMs - Q9H2G2 As Enzyme

Substrate Site Source
P61586 (RHOA) S188 Uniprot
Q9H2K8 (TAOK3) T181 Uniprot
Q9H2K8 (TAOK3) Y183 Uniprot

Research Backgrounds

Function:

Mediates apoptosis and actin stress fiber dissolution.

PTMs:

Proteolytically cleaved by caspase-3.

Autophosphorylated.

Subcellular Location:

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle.

Family&Domains:

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

Research Fields

· Cellular Processes > Cell growth and death > Oocyte meiosis.   (View pathway)

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