LMTK2 Antibody - #DF3344

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Product: LMTK2 Antibody
Catalog: DF3344
Description: Rabbit polyclonal antibody to LMTK2
Application: WB IHC IF/ICC
Reactivity: Human, Mouse
Prediction: Bovine, Horse, Sheep, Dog
Mol.Wt.: 164 KD; 165kD(Calculated).
Uniprot: Q8IWU2
RRID: AB_2835711

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:1000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Prediction:
Bovine(80%), Horse(80%), Sheep(90%), Dog(90%)
Clonality:
Polyclonal
Specificity:
LMTK2 Antibody detects endogenous levels of total LMTK2.
RRID:
AB_2835711
Cite Format: Affinity Biosciences Cat# DF3344, RRID:AB_2835711.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

AATYK 2; AATYK2; Apoptosis associated tyrosine kinase 2; Apoptosis-associated tyrosine kinase 2; Brain enriched kinase; Brain-enriched kinase; BREK; CDK5/p35 regulated kinase; CDK5/p35-regulated kinase; CPRK; cyclin-dependent kinase 5/p35-regulated kinase; FLJ46659; hBREK; KIAA1079; Kinase phosphatase inhibitor 2; Kinase/phosphatase/inhibitor 2; KPI 2; KPI-2; KPI2; Lemur tyrosine kinase 2; LMR 2; LMR2; LMTK 2; Lmtk2; LMTK2_HUMAN; PPP1R100; protein phosphatase 1, regulatory subunit 100; Serine/threonine protein kinase KPI 2; Serine/threonine protein kinase KPI2; Serine/threonine protein kinase LMTK 2; Serine/threonine protein kinase LMTK2; Serine/threonine-protein kinase KPI-2; Serine/threonine-protein kinase LMTK2;

Immunogens

Immunogen:
Uniprot:

Q8IWU2(LMTK2_HUMAN) >>Visit HPA database.

Gene(ID):
LMTK2(22853)
Expression:
Q8IWU2 LMTK2_HUMAN:

Mainly expressed in skeletal muscle, and weakly in brain and pancreas.

Sequence:
MPGPPALRRRLLLLLLVLLIAGSAGAAPLPQTGAGEAPPAAEVSSSFVILCVCSLIILIVLIANCVSCCKDPEIDFKEFEDNFDDEIDFTPPAEDTPSVQSPAEVFTLSVPNISLPAPSQFQPSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASANPKEQDTFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHMRGDSQTMLLQRMACEVAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDTKLPKPQLEQPYSDRWYEVLQFCWLSPEKRPAAEDVHRLLTYLRLQSQRDSEVDFEQQWNALKPNTNSRDSSNNAAFPILDHFARDRLGREMEEVLTVTETSQGLSFEYVWEAAKHDHFDERSRGHLDEGLSYTSIFYPVEVFESSLSDPGPGKQDDSGQDVPLRVPGVVPVFDAHNLSVGSDYYIQLEEKSGSNLELDYPPALLTTDMDNPERTGPELSQLTALRSVELEESSTDEDFFQSSTDPKDSSLPGDLHVTSGPESPFNNIFNDVDKSEDLPSHQKIFDLMELNGVQADFKPATLSSSLDNPKESVITGHFEKEKPRKIFDSEPLCLSDNLMHQDNFDPLNVQELSENFLFLQEKNLLKGSLSSKEHINDLQTELKNAGFTEAMLETSCRNSLDTELQFAENKPGLSLLQENVSTKGDDTDVMLTGDTLSTSLQSSPEVQVPPTSFETEETPRRVPPDSLPTQGETQPTCLDVIVPEDCLHQDISPDAVTVPVEILSTDARTHSLDNRSQDSPGESEETLRLTESDSVLADDILASRVSVGSSLPELGQELHNKPFSEDHHSHRRLEKNLEAVETLNQLNSKDAAKEAGLVSALSSDSTSQDSLLEDSLSAPFPASEPSLETPDSLESVDVHEALLDSLGSHTPQKLVPPDKPADSGYETENLESPEWTLHPAPEGTADSEPATTGDGGHSGLPPNPVIVISDAGDGHRGTEVTPETFTAGSQGSYRDSAYFSDNDSEPEKRSEEVPGTSPSALVLVQEQPLPEPVLPEQSPAAQDSCLEARKSQPDESCLSALHNSSDLELRATPEPAQTGVPQQVHPTEDEASSPWSVLNAELSSGDDFETQDDRPCTLASTGTNTNELLAYTNSALDKSLSSHSEGPKLKEPDIEGKYLGKLGVSGMLDLSEDGMDADEEDENSDDSDEDLRAFNLHSLSSESEDETEHPVPIILSNEDGRHLRSLLKPTAANAPDPLPEDWKKEKKAVTFFDDVTVYLFDQETPTKELGPCGGEACGPDLSGPAPASGSPYLSRCINSESSTDEEGGGFEWDDDFSPDPFMSKTTSNLLSSKPSLQTSKYFSPPPPARSTEQSWPHSAPYSRFSISPANIASFSLTHLTDSDIEQGGSSEDGEKD

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Sheep
90
Dog
90
Horse
80
Bovine
80
Chicken
63
Pig
60
Xenopus
0
Zebrafish
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q8IWU2 As Substrate

Site PTM Type Enzyme
T90 Phosphorylation
K150 Ubiquitination
K177 Ubiquitination
K223 Ubiquitination
K292 Ubiquitination
S418 Phosphorylation
K430 Ubiquitination
S473 Phosphorylation
Y476 Phosphorylation
S490 Phosphorylation
Y500 Phosphorylation
S525 Phosphorylation
T582 Phosphorylation
S587 Phosphorylation
S594 Phosphorylation
T602 Phosphorylation
S630 Phosphorylation
S671 Phosphorylation
S679 Phosphorylation
S788 Phosphorylation
T876 Phosphorylation
S883 Phosphorylation
S886 Phosphorylation
S901 Phosphorylation
S955 Phosphorylation
T996 Phosphorylation
S1012 Phosphorylation
T1088 Phosphorylation
Y1100 Phosphorylation
S1107 Phosphorylation
S1111 Phosphorylation
S1117 Phosphorylation
T1123 Phosphorylation
S1124 Phosphorylation
S1126 Phosphorylation
S1248 Phosphorylation
S1251 Phosphorylation
S1291 Phosphorylation
S1294 Phosphorylation
S1305 Phosphorylation
S1307 Phosphorylation
S1308 Phosphorylation
S1310 Phosphorylation
S1397 Phosphorylation
T1445 Phosphorylation
S1446 Phosphorylation
Y1448 Phosphorylation
S1450 Phosphorylation Q00535 (CDK5)
S1465 Phosphorylation
Y1468 Phosphorylation
S1489 Phosphorylation
S1496 Phosphorylation
S1497 Phosphorylation

PTMs - Q8IWU2 As Enzyme

Substrate Site Source
P11216 (PYGB) S15 Uniprot
P13569 (CFTR) S737 Uniprot
P62136 (PPP1CA) T320 Uniprot

Research Backgrounds

Function:

Phosphorylates PPP1C, phosphorylase b and CFTR.

PTMs:

Autophosphorylated. Phosphorylated (By similarity).

Subcellular Location:

Membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Mainly expressed in skeletal muscle, and weakly in brain and pancreas.

Subunit Structure:

Interacts with PPP1C and inhibitor-2.

Family&Domains:

Belongs to the protein kinase superfamily. Tyr protein kinase family.

References

1). LMTK2 regulates inflammation in lipopolysaccharide‑stimulated BV2 cells. Experimental and Therapeutic Medicine, 2021 (PubMed: 33603828) [IF=2.7]

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