ZNF638 Antibody - #DF3280
Product: | ZNF638 Antibody |
Catalog: | DF3280 |
Description: | Rabbit polyclonal antibody to ZNF638 |
Application: | WB IHC IF/ICC |
Reactivity: | Human |
Prediction: | Pig, Dog |
Mol.Wt.: | 220 KD; 221kD(Calculated). |
Uniprot: | Q14966 |
RRID: | AB_2835648 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF3280, RRID:AB_2835648.
Fold/Unfold
CTCL tumor antigen se33 1; CTCL-associated antigen se33-1; Cutaneous T cell lymphoma associated antigen se33 1; Cutaneous T-cell lymphoma-associated antigen se33-1; DKFZp686P1231; MGC26130; MGC90196; NP220; NP220 nuclear protein; Nuclear protein 220; ZFML; Zfp638; Zinc finger matrin like; Zinc finger matrin like protein; Zinc finger matrin-like protein; Zinc finger protein 638; ZN638_HUMAN; ZNF 638; Znf638;
Immunogens
- Q14966 ZN638_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSRPRFNPRGDFPLQRPRAPNPSGMRPPGPFMRPGSMGLPRFYPAGRARGIPHRFAGHESYQNMGPQRMNVQVTQHRTDPRLTKEKLDFHEAQQKKGKPHGSRWDDEPHISASVAVKQSSVTQVTEQSPKVQSRYTKESASSILASFGLSNEDLEELSRYPDEQLTPENMPLILRDIRMRKMGRRLPNLPSQSRNKETLGSEAVSSNVIDYGHASKYGYTEDPLEVRIYDPEIPTDEVENEFQSQQNISASVPNPNVICNSMFPVEDVFRQMDFPGESSNNRSFFSVESGTKMSGLHISGGQSVLEPIKSVNQSINQTVSQTMSQSLIPPSMNQQPFSSELISSVSQQERIPHEPVINSSNVHVGSRGSKKNYQSQADIPIRSPFGIVKASWLPKFSHADAQKMKRLPTPSMMNDYYAASPRIFPHLCSLCNVECSHLKDWIQHQNTSTHIESCRQLRQQYPDWNPEILPSRRNEGNRKENETPRRRSHSPSPRRSRRSSSSHRFRRSRSPMHYMYRPRSRSPRICHRFISRYRSRSRSRSPYRIRNPFRGSPKCFRSVSPERMSRRSVRSSDRKKALEDVVQRSGHGTEFNKQKHLEAADKGHSPAQKPKTSSGTKPSVKPTSATKSDSNLGGHSIRCKSKNLEDDTLSECKQVSDKAVSLQRKLRKEQSLHYGSVLLITELPEDGCTEEDVRKLFQPFGKVNDVLIVPYRKEAYLEMEFKEAITAIMKYIETTPLTIKGKSVKICVPGKKKAQNKEVKKKTLESKKVSASTLKRDADASKAVEIVTSTSAAKTGQAKASVAKVNKSTGKSASSVKSVVTVAVKGNKASIKTAKSGGKKSLEAKKTGNVKNKDSNKPVTIPENSEIKTSIEVKATENCAKEAISDAALEATENEPLNKETEEMCVMLVSNLPNKGYSVEEVYDLAKPFGGLKDILILSSHKKAYIEINRKAAESMVKFYTCFPVLMDGNQLSISMAPENMNIKDEEAIFITLVKENDPEANIDTIYDRFVHLDNLPEDGLQCVLCVGLQFGKVDHHVFISNRNKAILQLDSPESAQSMYSFLKQNPQNIGDHMLTCSLSPKIDLPEVQIEHDPELEKESPGLKNSPIDESEVQTATDSPSVKPNELEEESTPSIQTETLVQQEEPCEEEAEKATCDSDFAVETLELETQGEEVKEEIPLVASASVSIEQFTENAEECALNQQMFNSDLEKKGAEIINPKTALLPSDSVFAEERNLKGILEESPSEAEDFISGITQTMVEAVAEVEKNETVSEILPSTCIVTLVPGIPTGDEKTVDKKNISEKKGNMDEKEEKEFNTKETRMDLQIGTEKAEKNEGRMDAEKVEKMAAMKEKPAENTLFKAYPNKGVGQANKPDETSKTSILAVSDVSSSKPSIKAVIVSSPKAKATVSKTENQKSFPKSVPRDQINAEKKLSAKEFGLLKPTSARSGLAESSSKFKPTQSSLTRGGSGRISALQGKLSKLDYRDITKQSQETEARPSIMKRDDSNNKTLAEQNTKNPKSTTGRSSKSKEEPLFPFNLDEFVTVDEVIEEVNPSQAKQNPLKGKRKETLKNVPFSELNLKKKKGKTSTPRGVEGELSFVTLDEIGEEEDAAAHLAQALVTVDEVIDEEELNMEEMVKNSNSLFTLDELIDQDDCISHSEPKDVTVLSVAEEQDLLKQERLVTVDEIGEVEELPLNESADITFATLNTKGNEGDTVRDSIGFISSQVPEDPSTLVTVDEIQDDSSDLHLVTLDEVTEEDEDSLADFNNLKEELNFVTVDEVGEEEDGDNDLKVELAQSKNDHPTDKKGNRKKRAVDTKKTKLESLSQVGPVNENVMEEDLKTMIERHLTAKTPTKRVRIGKTLPSEKAVVTEPAKGEEAFQMSEVDEESGLKDSEPERKRKKTEDSSSGKSVASDVPEELDFLVPKAGFFCPICSLFYSGEKAMTNHCKSTRHKQNTEKFMAKQRKEKEQNEAEERSSR
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q14966 As Substrate
Site | PTM Type | Enzyme | Source |
---|---|---|---|
R33 | Methylation | Uniprot | |
S36 | Phosphorylation | Uniprot | |
R41 | Methylation | Uniprot | |
R47 | Methylation | Uniprot | |
R49 | Methylation | Uniprot | |
R54 | Methylation | Uniprot | |
Y61 | Phosphorylation | Uniprot | |
R68 | Methylation | Uniprot | |
K86 | Ubiquitination | Uniprot | |
T125 | Phosphorylation | Uniprot | |
S128 | Phosphorylation | Uniprot | |
K130 | Ubiquitination | Uniprot | |
S193 | Phosphorylation | Uniprot | |
K196 | Ubiquitination | Uniprot | |
K216 | Ubiquitination | Uniprot | |
S283 | Phosphorylation | Uniprot | |
S289 | Phosphorylation | Uniprot | |
S299 | Phosphorylation | Uniprot | |
S303 | Phosphorylation | Uniprot | |
S366 | Phosphorylation | Uniprot | |
R367 | Methylation | Uniprot | |
S369 | Phosphorylation | Uniprot | |
K371 | Ubiquitination | Uniprot | |
S375 | Phosphorylation | O14757 (CHEK1) | Uniprot |
R382 | Methylation | Uniprot | |
S383 | Phosphorylation | Uniprot | |
T409 | Phosphorylation | Uniprot | |
S420 | Phosphorylation | Uniprot | |
S488 | Phosphorylation | Uniprot | |
S490 | Phosphorylation | Uniprot | |
S492 | Phosphorylation | Uniprot | |
S499 | Phosphorylation | Uniprot | |
S502 | Phosphorylation | Uniprot | |
S508 | Phosphorylation | Uniprot | |
S510 | Phosphorylation | Uniprot | |
S520 | Phosphorylation | Uniprot | |
S522 | Phosphorylation | Uniprot | |
S541 | Phosphorylation | Uniprot | |
Y543 | Phosphorylation | Uniprot | |
S552 | Phosphorylation | Uniprot | |
R557 | Methylation | Uniprot | |
S558 | Phosphorylation | Uniprot | |
S560 | Phosphorylation | Uniprot | |
S568 | Phosphorylation | Uniprot | |
S571 | Phosphorylation | Uniprot | |
K576 | Ubiquitination | Uniprot | |
S585 | Phosphorylation | Uniprot | |
T589 | Phosphorylation | Uniprot | |
K593 | Ubiquitination | Uniprot | |
K602 | Ubiquitination | Uniprot | |
S605 | Phosphorylation | Uniprot | |
T612 | Phosphorylation | Uniprot | |
S614 | Phosphorylation | Uniprot | |
T616 | Phosphorylation | Uniprot | |
T623 | Phosphorylation | Uniprot | |
S624 | Phosphorylation | Uniprot | |
T626 | Phosphorylation | Uniprot | |
S628 | Phosphorylation | Uniprot | |
S630 | Phosphorylation | Uniprot | |
S636 | Phosphorylation | Uniprot | |
S641 | Phosphorylation | Uniprot | |
S650 | Phosphorylation | Uniprot | |
K653 | Ubiquitination | Uniprot | |
S656 | Phosphorylation | Uniprot | |
K658 | Ubiquitination | Uniprot | |
S671 | Phosphorylation | Uniprot | |
Y716 | Phosphorylation | Uniprot | |
Y731 | Phosphorylation | Uniprot | |
T738 | Phosphorylation | Uniprot | |
S770 | Phosphorylation | Uniprot | |
T773 | Phosphorylation | Uniprot | |
S791 | Phosphorylation | Uniprot | |
T795 | Phosphorylation | Uniprot | |
S801 | Phosphorylation | Uniprot | |
S808 | Phosphorylation | Uniprot | |
T809 | Phosphorylation | Uniprot | |
S815 | Phosphorylation | Uniprot | |
S818 | Phosphorylation | Uniprot | |
K853 | Acetylation | Uniprot | |
K868 | Acetylation | Uniprot | |
S885 | Phosphorylation | Uniprot | |
K927 | Ubiquitination | Uniprot | |
K943 | Ubiquitination | Uniprot | |
K951 | Acetylation | Uniprot | |
K951 | Ubiquitination | Uniprot | |
Y1060 | Phosphorylation | Uniprot | |
K1098 | Ubiquitination | Uniprot | |
S1100 | Phosphorylation | Uniprot | |
S1106 | Phosphorylation | Uniprot | |
S1119 | Phosphorylation | Uniprot | |
S1121 | Phosphorylation | Uniprot | |
S1158 | Phosphorylation | Uniprot | |
T1328 | Phosphorylation | Uniprot | |
K1330 | Acetylation | Uniprot | |
T1376 | Phosphorylation | Uniprot | |
S1377 | Phosphorylation | Uniprot | |
K1391 | Acetylation | Uniprot | |
K1391 | Ubiquitination | Uniprot | |
S1400 | Phosphorylation | Uniprot | |
S1401 | Phosphorylation | Uniprot | |
S1409 | Phosphorylation | Uniprot | |
K1430 | Ubiquitination | Uniprot | |
K1441 | Acetylation | Uniprot | |
K1455 | Acetylation | Uniprot | |
S1462 | Phosphorylation | Uniprot | |
R1465 | Methylation | Uniprot | |
S1468 | Phosphorylation | Uniprot | |
S1472 | Phosphorylation | Uniprot | |
K1477 | Acetylation | Uniprot | |
K1477 | Ubiquitination | Uniprot | |
S1479 | Phosphorylation | Uniprot | |
K1480 | Ubiquitination | Uniprot | |
S1575 | Phosphorylation | Uniprot | |
S1641 | Phosphorylation | Uniprot | |
S1656 | Phosphorylation | Uniprot | |
S1667 | Phosphorylation | Uniprot | |
K1676 | Ubiquitination | Uniprot | |
S1697 | Phosphorylation | Uniprot | |
S1797 | Phosphorylation | Uniprot | |
S1825 | Phosphorylation | Uniprot | |
T1851 | Phosphorylation | Uniprot | |
K1860 | Acetylation | Uniprot | |
K1866 | Acetylation | Uniprot | |
S1882 | Phosphorylation | Uniprot | |
S1888 | Phosphorylation | Uniprot | |
K1891 | Acetylation | Uniprot | |
S1893 | Phosphorylation | Uniprot | |
S1913 | Phosphorylation | Uniprot | |
S1938 | Phosphorylation | Uniprot | |
K1958 | Acetylation | Uniprot |
Research Backgrounds
Transcription factor that binds to cytidine clusters in double-stranded DNA. Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed. Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4. Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity).
Nucleus speckle.
Interacts with FHL2. Interacts with CEBPA, CEBPD and CEBPG (By similarity). Interacts with MPHOSPH8 and TASOR components of the HUSH complex; leading to recruitment of the HUSH complex. Interacts with SETDB1. Interacts with HDAC1. Interacts with HDAC4.
The matrin-type zinc finger domain is required for localization to nuclear speckles.
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