CGK2 Antibody - #DF3257
| Product: | CGK2 Antibody |
| Catalog: | DF3257 |
| Description: | Rabbit polyclonal antibody to CGK2 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse, Rat, Monkey |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 87 KD; 87kD(Calculated). |
| Uniprot: | Q13237 |
| RRID: | AB_2835637 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF3257, RRID:AB_2835637.
Fold/Unfold
CGK 2; cGK2; cGKII; cGMP dependent protein kinase 2; cGMP-dependent protein kinase 2; cGMP-dependent protein kinase II; KGP2_HUMAN; PRKG 2; PRKG2; PRKGR2; Protein kinase, cGMP dependent, type II; Type II cGMP dependent protein kinase;
Immunogens
- Q13237 KGP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSKQTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRSMSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKDF
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q13237 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| G2 | Myristoylation | Uniprot | |
| S11 | Phosphorylation | Uniprot | |
| S97 | Phosphorylation | Q13237 (PRKG2) | Uniprot |
| T109 | Phosphorylation | Uniprot | |
| S110 | Phosphorylation | Q13237 (PRKG2) | Uniprot |
| S114 | Phosphorylation | Q13237 (PRKG2) | Uniprot |
| S117 | Phosphorylation | Q13237 (PRKG2) | Uniprot |
| S126 | Phosphorylation | Q13237 (PRKG2) | Uniprot |
| T131 | Phosphorylation | Uniprot | |
| K157 | Ubiquitination | Uniprot | |
| K165 | Sumoylation | Uniprot | |
| K165 | Ubiquitination | Uniprot | |
| Y306 | Phosphorylation | Uniprot | |
| Y307 | Phosphorylation | Uniprot | |
| S431 | Phosphorylation | Uniprot | |
| S445 | Phosphorylation | Q13237 (PRKG2) | Uniprot |
| S448 | Phosphorylation | Uniprot | |
| K521 | Methylation | Uniprot |
PTMs - Q13237 As Enzyme
| Substrate | Site | Source |
|---|---|---|
| P04626 (ERBB2) | T686 | Uniprot |
| P04792 (HSPB1) | S78 | Uniprot |
| P04792 (HSPB1) | S82 | Uniprot |
| P04792 (HSPB1) | T143 | Uniprot |
| P29474 (NOS3) | T495 | Uniprot |
| P29474 (NOS3) | S633 | Uniprot |
| P29474 (NOS3) | S1177 | Uniprot |
| P30307 (CDC25C) | S216 | Uniprot |
| P32929 (CTH) | S377 | Uniprot |
| P42261 (GRIA1) | S863 | Uniprot |
| P48436 (SOX9) | S181 | Uniprot |
| P49675 (STAR) | S56 | Uniprot |
| P49675 (STAR) | S57 | Uniprot |
| P49675 (STAR) | S100 | Uniprot |
| P49841 (GSK3B) | S9 | Uniprot |
| P50552 (VASP) | S239 | Uniprot |
| P53350 (PLK1) | S137 | Uniprot |
| P55211 (CASP9) | S196 | Uniprot |
| Q01970-1 (PLCB3) | S26 | Uniprot |
| Q01970-1 (PLCB3) | S1105 | Uniprot |
| Q03393 (PTS) | S19 | Uniprot |
| Q12778 (FOXO1) | S319 | Uniprot |
| Q13237 (PRKG2) | S97 | Uniprot |
| Q13237 (PRKG2) | S110 | Uniprot |
| Q13237 (PRKG2) | S114 | Uniprot |
| Q13237 (PRKG2) | S117 | Uniprot |
| Q13237 (PRKG2) | S126 | Uniprot |
| Q13237 (PRKG2) | S445 | Uniprot |
| Q14847-1 (LASP1) | S61 | Uniprot |
| Q14847 (LASP1) | S146 | Uniprot |
| Q15418 (RPS6KA1) | S380 | Uniprot |
| Q9UL51 (HCN2) | S668 | Uniprot |
Research Backgrounds
Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity).
Myristoylation mediates membrane localization.
Apical cell membrane>Lipid-anchor.
Highly concentrated in brain, lung and intestinal mucosa.
Interacts with GRIA1/GLUR1.
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.
Research Fields
· Cellular Processes > Cellular community - eukaryotes > Gap junction. (View pathway)
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Organismal Systems > Immune system > Platelet activation. (View pathway)
· Organismal Systems > Environmental adaptation > Circadian entrainment.
· Organismal Systems > Nervous system > Long-term depression.
· Organismal Systems > Sensory system > Olfactory transduction.
· Organismal Systems > Endocrine system > Regulation of lipolysis in adipocytes.
· Organismal Systems > Endocrine system > Renin secretion.
· Organismal Systems > Digestive system > Salivary secretion.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.