GAS3 Recombinant Rabbit mAb - #BF4588
Out of stock
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Product Info
Source:
Rabbit IgG
Application:
WB 1:1000, IHC 1:2000-1:20000, ICC
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Reactivity:
Human
Clonality:
Monoclonal [ReFirm24038]
Specificity:
GAS3 Recombinant Rabbit mAb detects endogenous levels of GAS3.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:
Fold/Unfold
CMT1A; CMT1E; DSS; GAS-3; GAS3; Growth Arrest Specific 3; Growth arrest-specific protein 3; HMSNIA; HNPP; MGC20769; Peripheral myelin protein 22; PMP-22; PMP22; PMP22_HUMAN; Sp110; Trembler;
Immunogens
Immunogen:
A synthetic peptide from human GAS3
Uniprot:
Gene(ID):
Description:
This gene encodes an integral membrane protein that is a major component of myelin in the peripheral nervous system. Studies suggest two alternately used promoters drive tissue-specific expression. Various mutations of this gene are causes of Charcot-Marie-Tooth disease Type IA,Dejerine-Sottas syndrome,and hereditary neuropathy with liability to pressure palsies. Alternative splicing results in multiple transcript variants.
Sequence:
- Q01453 PMP22_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLLLLLSIIVLHVAVLVLLFVSTIVSQWIVGNGHATDLWQNCSTSSSGNVHHCFSSSPNEWLQSVQATMILSIIFSILSLFLFFCQLFTLTKGGRFYITGIFQILAGLCVMSAAAIYTVRHPEWHLNSDYSYGFAYILAWVAFPLALLSGVIYVILRKRE
Research Backgrounds
Function:
Might be involved in growth regulation, and in myelinization in the peripheral nervous system.
Subcellular Location:
Cell membrane>Multi-pass membrane protein.
Family&Domains:
Belongs to the PMP-22/EMP/MP20 family.
Restrictive clause
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For Research Use Only.
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