MMP15 Antibody - #AF0213
| Product: | MMP15 Antibody |
| Catalog: | AF0213 |
| Description: | Rabbit polyclonal antibody to MMP15 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse |
| Prediction: | Bovine, Horse, Sheep, Dog, Chicken |
| Mol.Wt.: | 80kDa, 70 kDa; 76kD(Calculated). |
| Uniprot: | P51511 |
| RRID: | AB_2833283 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF0213, RRID:AB_2833283.
Fold/Unfold
AI503551; Matrix metallopeptidase 15 membrane inserted; Matrix metalloproteinase 15; Matrix metalloproteinase-15; Membrane type 2 matrix metalloproteinase; Membrane type matrix metalloproteinase 2; Membrane-type matrix metalloproteinase 2; Membrane-type-2 matrix metalloproteinase; MMP 15; MMP-15; MMP15; MMP15_HUMAN; MT MMP 2; MT-MMP 2; MT2 MMP; MT2-MMP; MT2MMP; MTMMP 2; MTMMP2; SMCP 2; SMCP-2; SMCP2;
Immunogens
Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle.
- P51511 MMP15_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGSDPSAPGRPGWTGSLLGDREEAARPRLLPLLLVLLGCLGLGVAAEDAEVHAENWLRLYGYLPQPSRHMSTMRSAQILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNICDGDFDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPISVWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNERLRMEPGYPKSILRDFMGCQEHVEPGPRWPDVARPPFNPHGGAEPGADSAEGDVGDGDGDFGAGVNKDGGSRVVVQMEEVARTVNVVMVLVPLLLLLCVLGLTYALVQMQRKGAPRVLLYCKRSLQEWV
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P51511 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S67 | Phosphorylation | Uniprot | |
| T305 | O-Glycosylation | Uniprot | |
| T313 | O-Glycosylation | Uniprot | |
| T318 | O-Glycosylation | Uniprot | |
| T320 | O-Glycosylation | Uniprot | |
| K388 | Ubiquitination | Uniprot | |
| S551 | Phosphorylation | Uniprot | |
| S589 | Phosphorylation | Uniprot | |
| Y660 | Phosphorylation | Uniprot | |
| K662 | Ubiquitination | Uniprot |
Research Backgrounds
Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.
The precursor is cleaved by a furin endopeptidase.
Membrane>Single-pass type I membrane protein>Extracellular side.
Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle.
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Belongs to the peptidase M10A family.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.