SFRS4 Antibody - #DF3245

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Product: SFRS4 Antibody
Catalog: DF3245
Description: Rabbit polyclonal antibody to SFRS4
Application: WB IF/ICC
Reactivity: Human, Mouse
Prediction: Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog
Mol.Wt.: 57 KD; 57kD(Calculated).
Uniprot: Q08170
RRID: AB_2835625

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Prediction:
Zebrafish(90%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%)
Clonality:
Polyclonal
Specificity:
SFRS4 Antibody detects endogenous levels of total SFRS4.
RRID:
AB_2835625
Cite Format: Affinity Biosciences Cat# DF3245, RRID:AB_2835625.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

arginine/serine-rich 4; Pre mRNA splicing factor SRP75; Pre-mRNA-splicing factor SRP75; Serine/arginine-rich splicing factor 4; Splicing factor; Splicing factor, arginine/serine rich 4; Splicing factor, arginine/serine rich, 75-KD; SRP001LB; SRP75; Srsf4; SRSF4_HUMAN;

Immunogens

Immunogen:
Uniprot:

Q08170(SRSF4_HUMAN) >>Visit HPA database.

Gene(ID):
SRSF4(6429)
Sequence:
MPRVYIGRLSYQARERDVERFFKGYGKILEVDLKNGYGFVEFDDLRDADDAVYELNGKDLCGERVIVEHARGPRRDGSYGSGRSGYGYRRSGRDKYGPPTRTEYRLIVENLSSRCSWQDLKDYMRQAGEVTYADAHKGRKNEGVIEFVSYSDMKRALEKLDGTEVNGRKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRSRSHSRS

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Zebrafish
90
Pig
0
Xenopus
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q08170 As Substrate

Site PTM Type Enzyme
R8 Methylation
K23 Ubiquitination
K27 Ubiquitination
Y53 Phosphorylation
K58 Ubiquitination
R71 Methylation
S78 Phosphorylation
S81 Phosphorylation
R83 Methylation
S84 Phosphorylation
S112 Phosphorylation
S113 Phosphorylation
S116 Phosphorylation
T131 Phosphorylation
Y132 Phosphorylation
S151 Phosphorylation
K154 Acetylation
K159 Ubiquitination
K176 Acetylation
S179 Phosphorylation
S186 Phosphorylation
S188 Phosphorylation
S190 Phosphorylation
S192 Phosphorylation
S222 Phosphorylation
S232 Phosphorylation
S238 Phosphorylation
S255 Phosphorylation
S257 Phosphorylation
S259 Phosphorylation
K264 Acetylation
S265 Phosphorylation
S267 Phosphorylation
S269 Phosphorylation
K287 Acetylation
S288 Phosphorylation
S290 Phosphorylation
S292 Phosphorylation
S300 Phosphorylation
S302 Phosphorylation
S304 Phosphorylation
S316 Phosphorylation
S318 Phosphorylation
S322 Phosphorylation
S360 Phosphorylation
S364 Phosphorylation
S368 Phosphorylation
S410 Phosphorylation
S412 Phosphorylation
S420 Phosphorylation
R428 Methylation
S431 Phosphorylation
T436 Phosphorylation
T440 Phosphorylation
S442 Phosphorylation
S446 Phosphorylation
S448 Phosphorylation
S450 Phosphorylation
S456 Phosphorylation
S458 Phosphorylation
S460 Phosphorylation
S462 Phosphorylation

Research Backgrounds

Function:

Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10.

PTMs:

Extensively phosphorylated on serine residues in the RS domain.

Subcellular Location:

Nucleus speckle.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Interacts with PNN.

Family&Domains:

Belongs to the splicing factor SR family.

Research Fields

· Genetic Information Processing > Transcription > Spliceosome.

· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.

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