Cyclophilin B Recombinant Rabbit mAb - #BF4329

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Product: Cyclophilin B Recombinant Rabbit mAb
Catalog: BF4329
Description: Rabbit monoclonal antibody to Cyclophilin B
Application: WB
Reactivity: Human, Mouse, Rat
Mol.Wt.: 20 kDa(Observed); 24kD(Calculated).
Uniprot: P23284

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Related Downloads
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit IgG
Application:
WB 1:1000-1:5000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human, Mouse, Rat
Clonality:
Monoclonal [ReFirm23779]
Specificity:
Cyclophilin B Recombinant Rabbit mAb detects endogenous levels of Cyclophilin B.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

AA408962; AA553318; AI844835; Cphn 2; Cphn2; Cyclophilin B; Cyclophilin like protein; CyP 20b; CYP S1; CYP-S1; CYPB; EC 5.2.1.8; MGC14109; MGC2224; OI9; peptidyl prolyl cis trans isomerase B; Peptidyl prolyl cis trans isomerase B precursor; Peptidyl-prolyl cis-trans isomerase B; peptidylprolyl isomerase B (cyclophilin B); Peptidylprolyl isomerase B; PPIase; PPIase B; Ppib; PPIB_HUMAN; Rotamase; Rotamase B; S cyclophilin; S-cyclophilin; SCYLP;

Immunogens

Immunogen:

A synthetic peptide from human Cyclophilin B

Uniprot:

P23284(PPIB_HUMAN) >>Visit HPA database.

Gene(ID):
PPIB(5479)
Description:
The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes,and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta.
Sequence:
MLRLSERNMKVLLAAALIAGSVFFLLLPGPSAADEKKKGPKVTVKVYFDLRIGDEDVGRVIFGLFGKTVPKTVDNFVALATGEKGFGYKNSKFHRVIKDFMIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE

Research Backgrounds

Function:

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.

Subcellular Location:

Endoplasmic reticulum lumen. Melanosome.
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065).

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Family&Domains:

Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.

Restrictive clause

 

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For Research Use Only.
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