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Control Products
Product Info
Source:
Rabbit IgG
Application:
WB 1:1000-1:3000, IHC 1:50-1:100, ICC
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Reactivity:
Human, Mouse, Rat
Clonality:
Monoclonal [ReFirm23438]
Specificity:
Lumican Recombinant Rabbit mAb detects endogenous levels of Lumican.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:
Fold/Unfold
Keratan sulfate proteoglycan lumican; KSPG lumican; LDC; LUM; LUM_HUMAN; Lumican; Lumican precursor; SLRR2D;
Immunogens
Immunogen:
A synthetic peptide from human Lumican
Uniprot:
Gene(ID):
Expression:
Description:
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin,biglycan,fibromodulin,keratocan,epiphycan,and osteoglycin. In these bifunctional molecules,the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth,corneal transparency,and epithelial cell migration and tissue repair.
Sequence:
- P51884 LUM_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSLSAFTLFLALIGGTSGQYYDYDFPLSIYGQSSPNCAPECNCPESYPSAMYCDELKLKSVPMVPPGIKYLYLRNNQIDHIDEKAFENVTDLQWLILDHNLLENSKIKGRVFSKLKQLKKLHINHNNLTESVGPLPKSLEDLQLTHNKITKLGSFEGLVNLTFIHLQHNRLKEDAVSAAFKGLKSLEYLDLSFNQIARLPSGLPVSLLTLYLDNNKISNIPDEYFKRFNALQYLRLSHNELADSGIPGNSFNVSSLVELDLSYNKLKNIPTVNENLENYYLEVNQLEKFDIKSFCKILGPLSYSKIKHLRLDGNRISETSLPPDMYECLRVANEVTLN
Research Backgrounds
PTMs:
Sulfated on tyrosine residue(s).
Subcellular Location:
Secreted>Extracellular space>Extracellular matrix.
Tissue Specificity:
Cornea and other tissues.
Family&Domains:
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
Research Fields
· Human Diseases > Cancers: Overview > Proteoglycans in cancer.
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