FXR2 Antibody - #DF3195

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Product: FXR2 Antibody
Catalog: DF3195
Description: Rabbit polyclonal antibody to FXR2
Application: WB IHC IF/ICC
Reactivity: Human, Mouse
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog
Mol.Wt.: 75kD, 95kD, 115kD; 74kD(Calculated).
Uniprot: P51116
RRID: AB_2835554

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:1000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Prediction:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%)
Clonality:
Polyclonal
Specificity:
FXR2 Antibody detects endogenous levels of total FXR2.
RRID:
AB_2835554
Cite Format: Affinity Biosciences Cat# DF3195, RRID:AB_2835554.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

FMR1L2; Fragile X mental retardation 1 like 2; Fragile X mental retardation autosomal homolog 2; Fragile X mental retardation gene autosomal homolog 2; Fragile X mental retardation syndrome related protein 2; Fragile X mental retardation syndrome-related protein 2; FXR 2; FXR2; FXR2 PEN; FXR2_HUMAN; FXR2P; Human fragile X mental retardation syndrome related protein FXR2 mRNA complete cds;

Immunogens

Immunogen:
Uniprot:

P51116(FXR2_HUMAN) >>Visit HPA database.

Gene(ID):
FXR2(9513)
Sequence:
MGGLASGGDVEPGLPVEVRGSNGAFYKGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPPPADYNKEITEGDEVEVYSRANEQEPCGWWLARVRMMKGDFYVIEYAACDATYNEIVTLERLRPVNPNPLATKGSFFKVTMAVPEDLREACSNENVHKEFKKALGANCIFLNITNSELFILSTTEAPVKRASLLGDMHFRSLRTKLLLMSRNEEATKHLETSKQLAAAFQEEFTVREDLMGLAIGTHGANIQQARKVPGVTAIELGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRVEGDNDKKNPREEGMVPFIFVGTRENISNAQALLEYHLSYLQEVEQLRLERLQIDEQLRQIGLGFRPPGSGRGSGGSDKAGYSTDESSSSSLHATRTYGGSYGGRGRGRRTGGPAYGPSSDVSTASETESEKREEPNRAGPGDRDPPTRGEESRRRPTGGRGRGPPPAPRPTSRYNSSSISSVLKDPDSNPYSLLDTSEPEPPVDSEPGEPPPASARRRRSRRRRTDEDRTVMDGGLESDGPNMTENGLEDESRPQRRNRSRRRRNRGNRTDGSISGDRQPVTVADYISRAESQSRQRPPLERTKPSEDSLSGQKGDSVSKLPKGPSENGELSAPLELGSMVNGVS

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P51116 As Substrate

Site PTM Type Enzyme
S6 Phosphorylation
S21 Phosphorylation
Y26 Phosphorylation
T70 Phosphorylation
Y113 Phosphorylation
S192 Phosphorylation
K205 Ubiquitination
K256 Ubiquitination
K305 Ubiquitination
K312 Ubiquitination
K320 Ubiquitination
T350 Phosphorylation
R393 Methylation
S397 Phosphorylation
R399 Methylation
S404 Phosphorylation
Y409 Phosphorylation
S410 Phosphorylation
T411 Phosphorylation
S414 Phosphorylation
S415 Phosphorylation
S416 Phosphorylation
S418 Phosphorylation
R432 Methylation
R434 Methylation
R436 Methylation
S446 Phosphorylation
S447 Phosphorylation
S450 Phosphorylation
T451 Phosphorylation
S453 Phosphorylation
T455 Phosphorylation
S457 Phosphorylation
R488 Methylation
R490 Methylation
S500 Phosphorylation
S504 Phosphorylation
S506 Phosphorylation
S509 Phosphorylation
K512 Ubiquitination
Y519 Phosphorylation
S520 Phosphorylation
T524 Phosphorylation
S525 Phosphorylation
S533 Phosphorylation
S548 Phosphorylation
T553 Phosphorylation
R557 Methylation
S566 Phosphorylation
T572 Phosphorylation
S580 Phosphorylation
T598 Phosphorylation
S601 Phosphorylation
S603 Phosphorylation
T610 Phosphorylation
Y614 Phosphorylation
S620 Phosphorylation
S634 Phosphorylation
S637 Phosphorylation
S639 Phosphorylation
S645 Phosphorylation
S647 Phosphorylation
S654 Phosphorylation

Research Backgrounds

Function:

RNA-binding protein.

Subcellular Location:

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Interacts with FMR1. Interacts with FXR1. Interacts with TDRD3. Interacts with HABP4. Interacts with CYFIP2 but not with CYFIP1 (By similarity).

(Microbial infection) Interacts with Sindbis virus non-structural protein 3 (via C-terminus); this interaction inhibits the formation of host stress granules on viral mRNAs and the nsp3-FXR2 complexes bind viral RNAs and probably orchestrate the assembly of viral replication complexes.

Family&Domains:

The tandem Agenet-like domains preferentially recognize trimethylated histone peptides.

Belongs to the FMR1 family.

Research Fields

· Genetic Information Processing > Translation > RNA transport.

References

1). Oleanolic acid alleviates ANIT-induced cholestatic liver injury by activating Fxr and Nrf2 pathways to ameliorate disordered bile acids homeostasis. PHYTOMEDICINE, 2022 (PubMed: 35605478) [IF=7.9]

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