ETV6 / Tel Antibody - #DF3174
| Product: | ETV6 / Tel Antibody |
| Catalog: | DF3174 |
| Description: | Rabbit polyclonal antibody to ETV6 / Tel |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 53 KD; 53kD(Calculated). |
| Uniprot: | P41212 |
| RRID: | AB_2835550 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF3174, RRID:AB_2835550.
Fold/Unfold
ETS related protein Tel1; ETS translocation variant 6; Ets variant 6; Ets variant gene 6 (TEL oncogene); ETS-related protein Tel1; ETV 6; ETV6; ETV6_HUMAN; Tel; TEL oncogene; TEL/ABL; TEL1; TEL1 oncogene; Transcription factor ETV 6; Transcription factor ETV6;
Immunogens
- P41212 ETV6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVYQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEHLESQELDEQIYQEDEC
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P41212 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Phosphorylation | Uniprot | |
| T4 | Phosphorylation | Uniprot | |
| K11 | Acetylation | Uniprot | |
| K11 | Sumoylation | Uniprot | |
| S16 | Phosphorylation | Uniprot | |
| Y17 | Phosphorylation | Uniprot | |
| T18 | Phosphorylation | Uniprot | |
| S22 | Phosphorylation | Q16539 (MAPK14) | Uniprot |
| S26 | Phosphorylation | Uniprot | |
| Y27 | Phosphorylation | Uniprot | |
| S29 | Phosphorylation | Uniprot | |
| S30 | Phosphorylation | Uniprot | |
| T31 | Phosphorylation | Uniprot | |
| S47 | Phosphorylation | Uniprot | |
| Y60 | Phosphorylation | Uniprot | |
| K99 | Sumoylation | Uniprot | |
| S131 | Phosphorylation | Uniprot | |
| S139 | Phosphorylation | Uniprot | |
| T142 | Phosphorylation | Uniprot | |
| T161 | Phosphorylation | Uniprot | |
| S165 | Phosphorylation | Uniprot | |
| S182 | Phosphorylation | Uniprot | |
| S184 | Phosphorylation | Uniprot | |
| T187 | Phosphorylation | Uniprot | |
| T188 | Phosphorylation | Uniprot | |
| S193 | Phosphorylation | Uniprot | |
| S203 | Phosphorylation | Uniprot | |
| S213 | Phosphorylation | P27361 (MAPK3) | Uniprot |
| S238 | Phosphorylation | Uniprot | |
| S257 | Phosphorylation | Q16539 (MAPK14) , P27361 (MAPK3) | Uniprot |
| S271 | Phosphorylation | Uniprot | |
| S284 | Phosphorylation | Uniprot | |
| S293 | Phosphorylation | Uniprot | |
| K302 | Acetylation | Uniprot | |
| K302 | Ubiquitination | Uniprot | |
| Y314 | Phosphorylation | Uniprot | |
| S323 | Phosphorylation | Uniprot | |
| K384 | Ubiquitination | Uniprot | |
| K393 | Ubiquitination | Uniprot | |
| Y401 | Phosphorylation | Uniprot | |
| Y402 | Phosphorylation | Uniprot | |
| K403 | Ubiquitination | Uniprot | |
| K421 | Sumoylation | Uniprot | |
| K421 | Ubiquitination | Uniprot | |
| T422 | Phosphorylation | Uniprot | |
| S439 | Phosphorylation | Uniprot | |
| Y447 | Phosphorylation | Uniprot |
Research Backgrounds
Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation.
Phosphorylation of Ser-257 by MAPK14 (p38) inhibits ETV6 transcriptional repression.
Nucleus.
Ubiquitous.
Can form homodimers or heterodimers with TEL2 or FLI1. Interacts with L3MBTL1 and HDAC9.
Belongs to the ETS family.
Research Fields
· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.
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