CD38 Recombinant Rabbit mAb - #BF3525

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Product: CD38 Recombinant Rabbit mAb
Catalog: BF3525
Description: Rabbit monoclonal antibody to CD38
Application: WB IHC
Reactivity: Human, Mouse
Mol.Wt.: 45 kDa(Observed); 34kD(Calculated).
Uniprot: P28907

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 100ul $280 In stock

Lead Time: Same day delivery

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Related Downloads
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit IgG
Application:
WB 1:1000, IHC 1:200-1:1000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Clonality:
Monoclonal [ReFirm22972]
Specificity:
CD38 Recombinant Rabbit mAb detects endogenous levels of CD38.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Acute lymphoblastic leukemia cells antigen CD38; ADP ribosyl cyclase 1; ADP ribosyl cyclase; ADP ribosyl cyclase/cyclic ADP-ribose hydrolase; ADP-ribosyl cyclase 1; ADPRC 1; ADPRC1; cADPr hydrolase 1; CD 38; CD38; CD38 antigen (p45); CD38 antigen; CD38 molecule; Cd38-rs1; CD38_HUMAN; CD38H; Cyclic ADP ribose hydrolase; Cyclic ADP ribose hydrolase 1; Cyclic ADP-ribose hydrolase 1; EC 3.2.2.5; Ecto nicotinamide adenine dinucleotide glycohydrolase; I-19; I19 (mouse); Lymphocyte differentiation antigen CD38; NAD(+) nucleosidase; NIM-R5 antigen; NIMR5 antigen (mouse); OTTHUMP00000158633; OTTHUMP00000217743; p45; T10;

Immunogens

Immunogen:

A synthetic peptide from human CD38

Uniprot:

P28907(CD38_HUMAN) >>Visit HPA database.

Gene(ID):
CD38(952)
Expression:
P28907 CD38_HUMAN:

Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.

Description:
The protein encoded by this gene is a non-lineage-restricted,type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose,an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail,a single membrane-spanning domain,and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer,with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants.
Sequence:
MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI

Research Backgrounds

Function:

Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

Subcellular Location:

Membrane>Single-pass type II membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.

Family&Domains:

Belongs to the ADP-ribosyl cyclase family.

Research Fields

· Environmental Information Processing > Signal transduction > Calcium signaling pathway.   (View pathway)

· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.

· Metabolism > Metabolism of cofactors and vitamins > Nicotinate and nicotinamide metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

· Organismal Systems > Immune system > Hematopoietic cell lineage.   (View pathway)

· Organismal Systems > Endocrine system > Oxytocin signaling pathway.

· Organismal Systems > Digestive system > Salivary secretion.

· Organismal Systems > Digestive system > Pancreatic secretion.

Restrictive clause

 

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For Research Use Only.
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