SLC31A1 / CTR1 Recombinant Rabbit mAb - #BF3373

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Product: SLC31A1 / CTR1 Recombinant Rabbit mAb
Catalog: BF3373
Description: Rabbit monoclonal antibody to SLC31A1 / CTR1
Application: WB
Reactivity: Human, Mouse, Rat
Mol.Wt.: 26-34 kDa(Observed); 21kD(Calculated).
Uniprot: O15431

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 100ul $280 In stock

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Data Sheet
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Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit IgG
Application:
WB 1:1000-1:5000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Monoclonal [ReFirm22820]
Specificity:
SLC31A1 / CTR1 Recombinant Rabbit mAb detects endogenous levels of SLC31A1 / CTR1.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Copper transport 1 homolog; Copper transporter 1; COPT1; COPT1_HUMAN; CTR1; hCTR1; High affinity copper uptake protein 1; SLC31A1; solute carrier family 31 (copper tansporters) member 1; Solute carrier family 31 member 1;

Immunogens

Immunogen:

A synthetic peptide from human SLC31A1

Uniprot:

O15431(COPT1_HUMAN) >>Visit HPA database.

Gene(ID):
SLC31A1(1317)
Description:
The protein encoded by this gene is a high-affinity copper transporter found in the cell membrane. The encoded protein functions as a homotrimer to effect the uptake of dietary copper.
Sequence:
MDHSHHMGMSYMDSNSTMQPSHHHPTTSASHSHGGGDSSMMMMPMTFYFGFKNVELLFSGLVINTAGEMAGAFVAVFLLAMFYEGLKIARESLLRKSQVSIRYNSMPVPGPNGTILMETHKTVGQQMLSFPHLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKAVVVDITEHCH

Research Backgrounds

Function:

High-affinity, saturable copper transporter involved in dietary copper uptake.

PTMs:

O-Glycosylation at Thr-27 protects from proteolytic cleavage in the N-terminal extracellular domain.

Subcellular Location:

Cell membrane>Multi-pass membrane protein.
Note: Localizes to the apical membrane in intestinal epithelial cells.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Family&Domains:

Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.

Research Fields

· Human Diseases > Drug resistance: Antineoplastic > Platinum drug resistance.

· Organismal Systems > Digestive system > Mineral absorption.

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