FRK Antibody - #DF3179
Product: | FRK Antibody |
Catalog: | DF3179 |
Description: | Rabbit polyclonal antibody to FRK |
Application: | WB IHC IF/ICC |
Reactivity: | Human, Mouse, Rat |
Prediction: | Pig, Bovine, Sheep, Dog |
Mol.Wt.: | 55 KD; 58kD(Calculated). |
Uniprot: | P42685 |
RRID: | AB_2835402 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF3179, RRID:AB_2835402.
Fold/Unfold
Beta cell Src homology tyrosine kinase; BSK; BSK/IYK; C85044; Frk; Frk fyn related kinase; FRK_HUMAN; FYN related kinase; FYN-related kinase; GASK; Gastrointestinal associated kinase; Gastrointestinal associated tyrosine kinase; GTK; GTK, mouse, homolog of; Intestine tyrosine kinase; Nuclear tyrosine protein kinase RAK; Protein-tyrosine kinase 5; PTK5; PTK5 protein tyrosine kinase 5; RAK; Tyrosine protein kinase FRK; Tyrosine-protein kinase FRK;
Immunogens
Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.
- P42685 FRK_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETDSSYSDANNFIR
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P42685 As Substrate
Site | PTM Type | Enzyme | Source |
---|---|---|---|
S37 | Phosphorylation | Uniprot | |
S40 | Phosphorylation | Uniprot | |
Y46 | Phosphorylation | Uniprot | |
Y53 | Phosphorylation | Uniprot | |
T57 | Phosphorylation | Uniprot | |
S62 | Phosphorylation | Uniprot | |
S92 | Phosphorylation | Uniprot | |
S93 | Phosphorylation | Uniprot | |
Y99 | Phosphorylation | Uniprot | |
S102 | Phosphorylation | Uniprot | |
Y104 | Phosphorylation | Uniprot | |
Y132 | Phosphorylation | Uniprot | |
S133 | Phosphorylation | Uniprot | |
S139 | Phosphorylation | Uniprot | |
T178 | Phosphorylation | Uniprot | |
S184 | Phosphorylation | Uniprot | |
Y193 | Phosphorylation | Uniprot | |
Y221 | Phosphorylation | Uniprot | |
S233 | Phosphorylation | Uniprot | |
Y303 | Phosphorylation | Uniprot | |
Y317 | Phosphorylation | Uniprot | |
Y368 | Phosphorylation | Uniprot | |
Y387 | Phosphorylation | P42685 (FRK) | Uniprot |
S389 | Phosphorylation | Uniprot | |
S407 | Phosphorylation | Uniprot | |
K409 | Acetylation | Uniprot | |
S495 | Phosphorylation | Uniprot | |
S496 | Phosphorylation | Uniprot | |
Y497 | Phosphorylation | P41240 (CSK) | Uniprot |
S498 | Phosphorylation | Uniprot |
PTMs - P42685 As Enzyme
Research Backgrounds
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
Cytoplasm. Nucleus.
Note: Predominantly found in the nucleus, with a small fraction found in the cell periphery.
Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.
Interacts (via the SH3-domain) with PTEN. Interacts with RB1.
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
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