CDC37 Antibody - #AF6458
| Product: | CDC37 Antibody |
| Catalog: | AF6458 |
| Description: | Rabbit polyclonal antibody to CDC37 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 44kDa; 44kD(Calculated). |
| Uniprot: | Q16543 |
| RRID: | AB_2835278 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF6458, RRID:AB_2835278.
Fold/Unfold
CDC 37; Cdc37; CDC37 cell division cycle 37 homolog; CDC37 cell division cycle 37 S cerevisiae homolog; CDC37 cell division cycle 37, S cerevisiae, homolog of; Cdc37 homolog; CDC37 protein; CDC37_HUMAN; CDC37A; cell division cycle 37; Cell division cycle 37 homolog; Hsp90 chaperone protein kinase targeting subunit; Hsp90 chaperone protein kinase targeting subunit p50Cdc37; Hsp90 chaperone protein kinase-targeting subunit; Hsp90 co chaperone Cdc37; Hsp90 co-chaperone Cdc37; p50; p50Cdc37; S cerevisiae hypothetical protein CDC37;
Immunogens
- Q16543 CDC37_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGGKAELERLQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLSKDGFSKSMVNTKPEKTEEDSEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKIKTADRQYMEGFNDELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKASEAKEGEEAGPGDPLLEAVPKTGDEKDVSV
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q16543 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| V2 | Acetylation | Uniprot | |
| Y4 | Phosphorylation | Uniprot | |
| S5 | Phosphorylation | Uniprot | |
| S13 | Phosphorylation | P19784 (CSNK2A2) , P68400 (CSNK2A1) | Uniprot |
| K45 | Acetylation | Uniprot | |
| K67 | Ubiquitination | Uniprot | |
| K69 | Acetylation | Uniprot | |
| K69 | Ubiquitination | Uniprot | |
| K78 | Acetylation | Uniprot | |
| K93 | Ubiquitination | Uniprot | |
| S97 | Phosphorylation | Uniprot | |
| K101 | Ubiquitination | Uniprot | |
| K110 | Ubiquitination | Uniprot | |
| S111 | Phosphorylation | Uniprot | |
| T118 | Phosphorylation | Uniprot | |
| S120 | Phosphorylation | Uniprot | |
| K121 | Ubiquitination | Uniprot | |
| K126 | Ubiquitination | Uniprot | |
| S127 | Phosphorylation | Uniprot | |
| T131 | Phosphorylation | Uniprot | |
| K132 | Sumoylation | Uniprot | |
| K135 | Ubiquitination | Uniprot | |
| T136 | Phosphorylation | Uniprot | |
| S140 | Phosphorylation | Uniprot | |
| K154 | Acetylation | Uniprot | |
| K157 | Acetylation | Uniprot | |
| K240 | Acetylation | Uniprot | |
| R246 | Methylation | Uniprot | |
| K260 | Ubiquitination | Uniprot | |
| Y278 | Phosphorylation | Uniprot | |
| Y298 | Phosphorylation | P07947 (YES1) | Uniprot |
| S300 | Phosphorylation | Uniprot | |
| K307 | Ubiquitination | Uniprot | |
| C308 | S-Nitrosylation | Uniprot | |
| K312 | Ubiquitination | Uniprot | |
| S322 | Phosphorylation | Uniprot | |
| K323 | Ubiquitination | Uniprot | |
| K330 | Acetylation | Uniprot | |
| K330 | Ubiquitination | Uniprot | |
| C336 | S-Nitrosylation | Uniprot | |
| S339 | Phosphorylation | Uniprot | |
| S346 | Phosphorylation | Uniprot | |
| K347 | Ubiquitination | Uniprot | |
| K352 | Ubiquitination | Uniprot | |
| K369 | Ubiquitination | Uniprot | |
| T370 | Phosphorylation | Uniprot | |
| K374 | Ubiquitination | Uniprot | |
| S377 | Phosphorylation | Uniprot |
Research Backgrounds
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Inhibits HSP90AA1 ATPase activity.
Constitutively sumoylated by UBE2I.
Cytoplasm.
Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2. Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23. Forms a complex with Hsp90/HSP90AB1 and CDK6. Interacts with HSP90AA1. Interacts with AR, CDK4, CDK6 and EIF2AK1. Interacts with RB1 (By similarity). Interacts with KSR1. Interacts with FLCN, FNIP1 and FNIP2.
Belongs to the CDC37 family.
Research Fields
· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway. (View pathway)
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