MTPAP Antibody - #DF15775
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Fold/Unfold
0610027A18Rik; AW551379; EC 2.7.7.19; FLJ10486; mitochondrial; Mitochondrial poly(A) polymerase; mtPAP; PAP; PAP-associated domain-containing protein 1; PAPD1; PAPD1_HUMAN; Poly(A) RNA polymerase; Poly(A) RNA polymerase, mitochondrial; Poly(A) RNA polymerase, mitochondrial precursor; Polynucleotide adenylyltransferase; RP11-305E6.3; Terminal uridylyltransferase 1; TUTase 1;
Immunogens
A synthesized peptide derived from human MTPAP.
Ubiquitous, with stronger expression in tissues with high energy requirements: heart, brain, and skeletal muscle.
- Q9NVV4 PAPD1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAVPGVGLLTRLNLCARRRTRVQRPIVRLLSCPGTVAKDLRRDEQPSGSVETGFEDKIPKRRFSEMQNERREQAQRTVLIHCPEKISENKFLKYLSQFGPINNHFFYESFGLYAVVEFCQKESIGSLQNGTHTPSTAMETAIPFRSRFFNLKLKNQTSERSRVRSSNQLPRSNKQLFELLCYAESIDDQLNTLLKEFQLTEENTKLRYLTCSLIEDMAAAYFPDCIVRPFGSSVNTFGKLGCDLDMFLDLDETRNLSAHKISGNFLMEFQVKNVPSERIATQKILSVLGECLDHFGPGCVGVQKILNARCPLVRFSHQASGFQCDLTTNNRIALTSSELLYIYGALDSRVRALVFSVRCWARAHSLTSSIPGAWITNFSLTMMVIFFLQRRSPPILPTLDSLKTLADAEDKCVIEGNNCTFVRDLSRIKPSQNTETLELLLKEFFEYFGNFAFDKNSINIRQGREQNKPDSSPLYIQNPFETSLNISKNVSQSQLQKFVDLARESAWILQQEDTDRPSISSNRPWGLVSLLLPSAPNRKSFTKKKSNKFAIETVKNLLESLKGNRTENFTKTSGKRTISTQT
Research Backgrounds
Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA.
Cytoplasm. Mitochondrion.
Ubiquitous, with stronger expression in tissues with high energy requirements: heart, brain, and skeletal muscle.
Homodimer.
Belongs to the DNA polymerase type-B-like family.
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