Product: NMRK2 Antibody
Catalog: DF15767
Description: Rabbit polyclonal antibody to NMRK2
Application: IHC
Reactivity: Human
Mol.Wt.: 26kD(Calculated).
Uniprot: Q9NPI5

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 100ul $280 In stock
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Product Info

Source:
Rabbit
Application:
IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
NMRK2 Antibody detects endogenous levels of NMRK2.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

2310015C21Rik,; Integrin beta 1 binding protein 3; Integrin beta-1-binding protein 3; Itgb1bp3; MGC126624; MIBP; Muscle integrin binding protein; Muscle integrin-binding protein; Muscle specific beta 1 integrin binding protein; Nicotinamide riboside kinase 2; Nicotinic acid riboside kinase 2; NmR K 2; NmR-K 2; NRK 2; NRK2; NRK2_HUMAN; Ribosylnicotinamide kinase 2; Ribosylnicotinic acid kinase 2; RNK 2;

Immunogens

Immunogen:

A synthesized peptide derived from human NMRK2.

Uniprot:
Gene(ID):
Expression:
Q9NPI5 NRK2_HUMAN:

Predominantly expressed in skeletal muscle and, at a much lower level, in the heart (at protein level). No expression in brain, kidney, liver, lung, pancreas nor placenta.

Sequence:
MKLIVGIGGMTNGGKTTLTNSLLRALPNCCVIHQDDFFKPQDQIAVGEDGFKQWDVLESLDMEAMLDTVQAWLSSPQKFARAHGVSVQPEASDTHILLLEGFLLYSYKPLVDLYSRRYFLTVPYEECKWRRSTRNYTVPDPPGLFDGHVWPMYQKYRQEMEANGVEVVYLDGMKSREELFREVLEDIQNSLLNRSQESAPSPARPARTQGPGRGCGHRTARPAASQQDSM

Research Backgrounds

Function:

Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis.

Tissue Specificity:

Predominantly expressed in skeletal muscle and, at a much lower level, in the heart (at protein level). No expression in brain, kidney, liver, lung, pancreas nor placenta.

Subunit Structure:

Monomer (By similarity). Interacts with ITGB1 alone or when associated with alpha-7, but not with alpha-5.

Family&Domains:

Belongs to the uridine kinase family. NRK subfamily.

Research Fields

· Metabolism > Metabolism of cofactors and vitamins > Nicotinate and nicotinamide metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

Restrictive clause

 

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