GUCA1C Antibody - #DF15602

Product: GUCA1C Antibody
Catalog: DF15602
Description: Rabbit polyclonal antibody to GUCA1C
Application: ELISA(peptide)
Reactivity: Human
Mol.Wt.: 24kD(Calculated).
Uniprot: O95843

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
ELISA(peptide) 1:20000-1:40000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
GUCA1C Antibody detects endogenous levels of GUCA1C.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

GCAP 3; Guanylate cyclase activating photoreceptor 3; Guanylate cyclase activator 1C; Guanylyl cyclase activating protein 3; Guanylyl cyclase-activating protein 3; GUC1C_HUMAN; GUCA1C;

Immunogens

Immunogen:

A synthesized peptide derived from human GUCA1C.

Uniprot:

O95843(GUC1C_HUMAN) >>Visit HPA database.

Gene(ID):
GUCA1C(9626)
Expression:
O95843 GUC1C_HUMAN:

Retina.

Sequence:
MGNGKSIAGDQKAVPTQETHVWYRTFMMEYPSGLQTLHEFKTLLGLQGLNQKANKHIDQVYNTFDTNKDGFVDFLEFIAAVNLIMQEKMEQKLKWYFKLYDADGNGSIDKNELLDMFMAVQALNGQQTLSPEEFINLVFHKIDINNDGELTLEEFINGMAKDQDLLEIVYKSFDFSNVLRVICNGKQPDMETDSSKSPDKAGLGKVKMK

Research Backgrounds

Function:

Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure.

Tissue Specificity:

Retina.

Family&Domains:

Binds three calcium ions (via EF-hand 2, 3 and 4).

Research Fields

· Organismal Systems > Sensory system > Phototransduction.

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