TMBIM6 Antibody - #DF15555

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Product: TMBIM6 Antibody
Catalog: DF15555
Description: Rabbit polyclonal antibody to TMBIM6
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 30kD; 27kD(Calculated).
Uniprot: P55061

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IF/ICC 1:100-1:500, IHC 1:50-1:200, WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
TMBIM6 Antibody detects endogenous levels of TMBIM6.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Bax inhibitor 1; BI 1; BI-1; BI1; BI1_HUMAN; TEGT; testis enhanced gene transcript (BAX inhibitor 1); Testis enhanced gene transcript; Testis-enhanced gene transcript protein; TMBIM 6; TMBIM6; Transmembrane BAX inhibitor motif containing 6; Transmembrane BAX inhibitor motif containing protein 6; Transmembrane BAX inhibitor motif-containing protein 6;

Immunogens

Immunogen:

A synthesized peptide derived from human TMBIM6.

Uniprot:

P55061(BI1_HUMAN) >>Visit HPA database.

Gene(ID):
TMBIM6(7009)
Expression:
P55061 BI1_HUMAN:

Highly abundant in testis.

Sequence:
MNIFDRKINFDALLKFSHITPSTQQHLKKVYASFALCMFVAAAGAYVHMVTHFIQAGLLSALGSLILMIWLMATPHSHETEQKRLGLLAGFAFLTGVGLGPALEFCIAVNPSILPTAFMGTAMIFTCFTLSALYARRRSYLFLGGILMSALSLLLLSSLGNVFFGSIWLFQANLYVGLVVMCGFVLFDTQLIIEKAEHGDQDYIWHCIDLFLDFITVFRKLMMILAMNEKDKKKEKK

Research Backgrounds

Function:

Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity).

Subcellular Location:

Endoplasmic reticulum membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Highly abundant in testis.

Subunit Structure:

Interacts with BCL2 and BCL2L1.

Family&Domains:

The intra-membrane loop at the C-terminus acts as a calcium pore, mediating calcium leak from the ER into the cytosol.

Belongs to the BI1 family.

Restrictive clause

 

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For Research Use Only.
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