PDE6C Antibody | Affinity Biosciences

IF/ICC

1/1

Product:	PDE6C Antibody
Catalog:	DF15448
Description:	Rabbit polyclonal antibody to PDE6C
Application:	IF/ICC
Reactivity:	Human, Mouse
Mol.Wt.:	99kD(Calculated).
Uniprot:	P51160

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Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific.

Size	Price	Inventory
100ul	$280	In stock
200ul	$350	In stock

Lead Time: Same day delivery

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Related Downloads

MS Report

HPLC Report

MSDS

Data Sheet

COA

Protocols

WB Handbook

IHC Protocol

IF/ICC Protocol

Product Info

Source:

Rabbit

Application:

IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:

Human,Mouse

Clonality:

Polyclonal

Specificity:

PDE6C Antibody detects endogenous levels of PDE6C.

Conjugate:

Unconjugated.

Purification:

The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Storage:

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Alias:

Fold/Unfold

5''-cyclic phosphodiesterase subunit alpha''; cGMP phosphodiesterase 6C; COD4; Cone cGMP specific 3' 5' cyclic phosphodiesterase subunit alpha'; Cone cGMP-specific 3''; PDE 6C; PDE6 alpha prime; PDE6 alpha'; PDE6C; PDE6C_HUMAN; PDEA2; Phosphodiesterase 6C cGMP specific cone alpha prime;

Immunogens

Immunogen:

A synthesized peptide derived from human PDE6C.

Uniprot:

P51160(PDE6C_HUMAN) >>Visit HPA database.

Gene(ID):

PDE6C(5146)

Sequence:

P51160 PDE6C_HUMAN:
Protein BLAST With
NCBI/
ExPASy/
Uniprot

MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML

Research Backgrounds

P51160_PDE6C_HUMAN

Function:

As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP.

Subcellular Location:

Cell membrane>Lipid-anchor>Cytoplasmic side.

Subunit Structure:

Composed of two alpha' subunits that are associated with 3 smaller proteins of 11, 13, and 15 kDa.

Family&Domains:

Belongs to the cyclic nucleotide phosphodiesterase family.

Research Fields

· Metabolism > Nucleotide metabolism > Purine metabolism.

Restrictive clause

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PDE6C Antibody - #DF15448