GREM1 Antibody - #DF15419
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Fold/Unfold
BMP antagonist 1; Cell proliferation inducing gene 2 protein; Cell proliferation-inducing gene 2 protein; CKTSF1B1; colorectal adenoma and carcinoma 1; Cysteine knot superfamily 1; Cysteine knot superfamily 1, BMP antagonist 1; Cysteine knot superfamily BMP antagonist 1; DAN domain family member 2; DAND2; Down regulated in Mos-transformed cells protein; Down-regulated in Mos-transformed cells protein; DRM; grem1; GREM1_HUMAN; Gremlin 1 homolog, cysteine knot superfamily; Gremlin 1 like protein; Gremlin 1, cysteine knot superfamily, homolog; GREMLIN; Gremlin-1; Gremlin1; IHG-2; IHG2; Increased in high glucose 2; Increased in high glucose protein 2; PIG2; Proliferation inducing gene 2; proliferation inducing gene 2 protein;
Immunogens
A synthesized peptide derived from human GREM1.
Highly expressed in small intestine, fetal brain and colon. Expression is restricted to intestinal subepithelial myofibroblasts (ISEMFs) at the crypt base. In subjects with HMPS1, by contrast, GREM1 is expressed, not only in basal ISEMFs, but also at very high levels in epithelial cells (predominantly colonocytes), with expression extending most of the way up the sides of the crypt. Weakly expressed in brain, ovary, prostate, pancreas and skeletal muscle. In brain found in the region localized around the internal capsule in the large subcortical nuclei, including caudate, putamen, substantia nigra, thalamus and subthalamus. Predominantly expressed in normal cells including neurons, astrocytes and fibroblasts.
- O60565 GREM1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD
Research Backgrounds
Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity).
Secreted.
Highly expressed in small intestine, fetal brain and colon. Expression is restricted to intestinal subepithelial myofibroblasts (ISEMFs) at the crypt base. In subjects with HMPS1, by contrast, GREM1 is expressed, not only in basal ISEMFs, but also at very high levels in epithelial cells (predominantly colonocytes), with expression extending most of the way up the sides of the crypt. Weakly expressed in brain, ovary, prostate, pancreas and skeletal muscle. In brain found in the region localized around the internal capsule in the large subcortical nuclei, including caudate, putamen, substantia nigra, thalamus and subthalamus. Predominantly expressed in normal cells including neurons, astrocytes and fibroblasts.
Homodimer; can also form homooligomers. Interacts with BMP2; can form higher oligomers with BMP2. Interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner (By similarity).
Belongs to the DAN family.
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