SCYL1 Antibody - #DF15273
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Fold/Unfold
Coated vesicle associated kinase of 90 kDa; Coated vesicle-associated kinase of 90 kDa; CVAK90; GKLP; HT019; Likely ortholog of mouse N terminal kinase like protein; MGC78454; N terminal kinase like; N terminal kinase like protein; N-terminal kinase-like protein; NKTL; NTKL; NTKL_HUMAN; NTKLBP1; P105; SCY L1; SCY1 like 1; SCY1 like 1 protein 1; SCY1-like protein 1; SCYL 1; Scyl1; SCYL1BP1; TAPK; TEIF; Telomerase regulation associated protein; Telomerase regulation-associated protein; Telomerase transcriptional element interacting factor; Telomerase transcriptional element-interacting factor; Teratoma associated tyrosine kinase; Teratoma-associated tyrosine kinase; TRAP;
Immunogens
A synthesized peptide derived from human SCYL1.
- Q96KG9 SCYL1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPELEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSSTDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKSMLLLAPKLNEANLNVELMKHFARLQAKDEQGPIRCNTTVCLGKIGSYLSASTRHRVLTSAFSRATRDPFAPSRVAGVLGFAATHNLYSMNDCAQKILPVLCGLTVDPEKSVRDQAFKAIRSFLSKLESVSEDPTQLEEVEKDVHAASSPGMGGAAASWAGWAVTGVSSLTSKLIRSHPTTAPTETNIPQRPTPEGVPAPAPTPVPATPTTSGHWETQEEDKDTAEDSSTADRWDDEDWGSLEQEAESVLAQQDDWSTGGQVSRASQVSNSDHKSSKSPESDWSSWEAEGSWEQGWQEPSSQEPPPDGTRLASEYNWGGPESSDKGDPFATLSARPSTQPRPDSWGEDNWEGLETDSRQVKAELARKKREERRREMEAKRAERKVAKGPMKLGARKLD
Research Backgrounds
Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology. Has no detectable kinase activity in vitro.
Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region.
Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus>cis-Golgi network.
Note: Localized to the Endoplasmic reticulum-Golgi intermediate and cis-Golgi in an ARF1-independent manner.
Cytoplasm.
Note: Cytoplasmic throughout the cell cycle.
Cytoplasm.
Note: Cytoplasmic throughout the cell cycle.
Cytoplasm. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome.
Note: Cytoplasmic during interphase and centrosomal during mitosis, it localizes to the centrosomes in a microtubule-independent manner.
Nucleus.
Ubiquitous.
Interacts with GORAB. Interacts with COPA, COPB1 and COPB2 (By similarity). Homooligomer. Interacts with AP2B1.
The protein kinase domain is predicted to be catalytically inactive.
Belongs to the protein kinase superfamily.
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