ELOVL7 Antibody - #DF14988

(2)  
Product: ELOVL7 Antibody
Catalog: DF14988
Description: Rabbit polyclonal antibody to ELOVL7
Application: WB IF/ICC
Reactivity: Human, Mouse
Mol.Wt.: 33kD(Calculated).
Uniprot: A1L3X0

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Clonality:
Polyclonal
Specificity:
ELOVL7 Antibody detects endogenous levels of ELOVL7.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

3-keto acyl-CoA synthase Elovl7; Elongation of very long chain fatty acids protein 7; ELOV7_HUMAN; ELOVL family member 7 elongation of long chain fatty acids; ELOVL family member 7 elongation of long chain fatty acids yeast; ELOVL fatty acid elongase 7; ELOVL7;

Immunogens

Immunogen:

A synthesized peptide derived from human ELOVL7.

Uniprot:

A1L3X0(ELOV7_HUMAN) >>Visit HPA database.

Gene(ID):
ELOVL7(79993)
Expression:
A1L3X0 ELOV7_HUMAN:

Expressed in most tissues except heart and skeletal muscle.

Sequence:
MAFSDLTSRTVHLYDNWIKDADPRVEDWLLMSSPLPQTILLGFYVYFVTSLGPKLMENRKPFELKKAMITYNFFIVLFSVYMCYEFVMSGWGIGYSFRCDIVDYSRSPTALRMARTCWLYYFSKFIELLDTIFFVLRKKNSQVTFLHVFHHTIMPWTWWFGVKFAAGGLGTFHALLNTAVHVVMYSYYGLSALGPAYQKYLWWKKYLTSLQLVQFVIVAIHISQFFFMEDCKYQFPVFACIIMSYSFMFLLLFLHFWYRAYTKGQRLPKTVKNGTCKNKDN

Research Backgrounds

Function:

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate in the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

Subcellular Location:

Endoplasmic reticulum membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in most tissues except heart and skeletal muscle.

Family&Domains:

The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

Belongs to the ELO family. ELOVL7 subfamily.

Research Fields

· Metabolism > Lipid metabolism > Fatty acid elongation.

Restrictive clause

 

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