Product: SLC47A2 Antibody
Catalog: DF14969
Description: Rabbit polyclonal antibody to SLC47A2
Application: IF/ICC
Reactivity: Human
Mol.Wt.: 65kD(Calculated).
Uniprot: Q86VL8

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Product Info

Source:
Rabbit
Application:
IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
SLC47A2 Antibody detects endogenous levels of SLC47A2.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

H(+)/organic cation antiporter kidney-specific; H+/organic cation antiporter; hMATE-2; Kidney-specific H(+)/organic cation antiporter; MATE-2; MATE2 B; MATE2 K; MATE2K; Multidrug and toxin extrusion 2; Multidrug and toxin extrusion protein 2; S47A2_HUMAN; SLC47A2; Solute carrier family 47 member 2;

Immunogens

Immunogen:

A synthesized peptide derived from human SLC47A2.

Uniprot:
Gene(ID):
Expression:
Q86VL8 S47A2_HUMAN:

Isoform 3 is predominantly expressed in kidney. Isoform 6 is expressed in brain.

Sequence:
MDSLQDTVALDHGGCCPALSRLVPRGFGTEMWTLFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCGVSVGVGLSSACDTLMSQSFGSPNKKHVGVILQRGALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQGWLKGQEEESPFQTPGLSILHPSHSHLSRASFHLFQKITWPQVLSGVVGNCVNGVANYALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSLAVPSMLMICVEWWAYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMIPLGLSIGVCVRVGMALGAADTVQAKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQAFGAAVNAITYYIIGLPLGILLTFVVRMRIMGLWLGMLACVFLATAAFVAYTARLDWKLAAEEAKKHSGRQQQQRAESTATRPGPEKAVLSSVATGSSPGITLTTYSRSECHVDFFRTPEEAHALSAPTSRLSVKQLVIRRGAALGAASATLMVGLTVRILATRH

Research Backgrounds

Function:

Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.

Subcellular Location:

Cell membrane>Multi-pass membrane protein.
Note: Localized at the brush border membranes of the proximal tubules.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Isoform 3 is predominantly expressed in kidney. Isoform 6 is expressed in brain.

Family&Domains:

Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.

Restrictive clause

 

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