JCHAIN Antibody - #DF14810

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Product: JCHAIN Antibody
Catalog: DF14810
Description: Rabbit polyclonal antibody to JCHAIN
Application: IHC IF/ICC
Reactivity: Human, Mouse
Mol.Wt.: 18kD(Calculated).
Uniprot: P01591

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 100ul $280 In stock
 200ul $350 In stock

Lead Time: Same day delivery

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Clonality:
Polyclonal
Specificity:
JCHAIN Antibody detects endogenous levels of JCHAIN.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

IGCJ; IGJ_HUMAN; Immunoglobulin J chain; Immunoglobulin J polypeptide linker protein for immunoglobulin alpha and mu polypeptides; immunoglobulin joining chain; JCH; JCHAIN; Joining chain of multimeric IgA and IgM;

Immunogens

Immunogen:

A synthesized peptide derived from human JCHAIN.

Uniprot:

P01591(IGJ_HUMAN) >>Visit HPA database.

Gene(ID):
JCHAIN(3512)
Sequence:
MKNHLLFWGVLAVFIKAVHVKAQEDERIVLVDNKCKCARITSRIIRSSEDPNEDIVERNIRIIVPLNNRENISDPTSPLRTRFVYHLSDLCKKCDPTEVELDNQIVTATQSNICDEDSATETCYTYDRNKCYTAVVPLVYGGETKMVETALTPDACYPD

Research Backgrounds

Function:

Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.

Subcellular Location:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location

References

1). Single cell analysis unveils B cell-dominated immune subtypes in HNSCC for enhanced prognostic and therapeutic stratification. International journal of oral science, 2024 (PubMed: 38622125) [IF=14.9]

Application: IHC    Species: Human    Sample:

Fig. 6 Unveiling a four-gene risk model for prognostication in HNSCC patients. a Comparative boxplot delineating the modeling-related gene expression levels within the two groups. b Forest plot mapping out OS-related clinical factors via single-factor Cox regression analysis. c Kaplan–Meier survival plots manifesting prognosis-linked risk scores’ impact. d ROC curve spectra, a predictive gauge for 1, 3, 5, and 10-year OS dynamics. e Comparative analysis spotlighting differential gene expressions between high and low-risk groups. f Kaplan-Meier survival curves of HNSCC patients based on four genes Risk-scores. Representative IHC staining images (g) and IHC score (h) in the two groups. Scale bar, 100 μm

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