RAMP3 Antibody - #DF14693

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Product: RAMP3 Antibody
Catalog: DF14693
Description: Rabbit polyclonal antibody to RAMP3
Application: IF/ICC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 17kD(Calculated).
Uniprot: O60896

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
RAMP3 Antibody detects endogenous levels of RAMP3.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Calcitonin receptor like receptor activity modifying protein 3; CRLR activity modifying protein 3; CRLR activity-modifying protein 3; OTTHUMP00000159549; OTTHUMP00000214279; OTTHUMP00000214280; Receptor (calcitonin) activity modifying protein 3; Receptor (G protein-coupled) activity modifying protein 3; Receptor activity modifying protein 3;

Immunogens

Immunogen:

A synthesized peptide derived from human RAMP3.

Uniprot:

O60896(RAMP3_HUMAN) >>Visit HPA database.

Gene(ID):
RAMP3(10268)
Expression:
O60896 RAMP3_HUMAN:

Strongly expressed in lung, breast, immune system and fetal tissues.

Sequence:
METGALRRPQLLPLLLLLCGGCPRAGGCNETGMLERLPLCGKAFADMMGKVDVWKWCNLSEFIVYYESFTNCTEMEANVVGCYWPNPLAQGFITGIHRQFFSNCTVDRVHLEDPPDEVLIPLIVIPVVLTVAMAGLVVWRSKRTDTLL

Research Backgrounds

Function:

Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.

Subcellular Location:

Cell membrane>Single-pass type I membrane protein. Membrane>Single-pass type I membrane protein.
Note: Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Strongly expressed in lung, breast, immune system and fetal tissues.

Subunit Structure:

Heterodimer of CALCRL and RAMP3 (By similarity). Interacts with GPER1.

Family&Domains:

Belongs to the RAMP family.

Research Fields

· Organismal Systems > Circulatory system > Vascular smooth muscle contraction.   (View pathway)

References

1). Adrenomedullin ameliorates palmitic acid-induced insulin resistance through PI3K/Akt pathway in adipocytes. ACTA DIABETOLOGICA, 2022 (PubMed: 34978596) [IF=3.8]

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