SEPSECS Antibody - #DF14590

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Product: SEPSECS Antibody
Catalog: DF14590
Description: Rabbit polyclonal antibody to SEPSECS
Application: IF/ICC
Reactivity: Human, Mouse
Mol.Wt.: 56kD(Calculated).
Uniprot: Q9HD40

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Clonality:
Polyclonal
Specificity:
SEPSECS Antibody detects endogenous levels of SEPSECS.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

DKFZp434B1417; Liver pancreas antigen; Liver-pancreas antigen; LP; MGC161491; O phosphoseryl tRNA(Sec) selenium transferase; O-phosphoseryl-tRNA(Sec) selenium transferase; Sec synthase; Selenocysteine synthase; Selenocysteinyl tRNA(Sec) synthase; Selenocysteinyl-tRNA(Sec) synthase; Sep (O phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase; Sep tRNA:Sec tRNA synthase; Sep-tRNA:Sec-tRNA synthase; SepSecS; SLA; SLA p35; SLA-p35; SLA/LP; SLA/LP autoantigen; Soluble liver antigen; Soluble liver antigen/liver pancreas antigen; Soluble Liver/Pancreas Antigen; SPCS_HUMAN; tRNA(Ser/Sec) associated antigenic protein; tRNA(Ser/Sec)-associated antigenic protein; TRNP48; UGA suppressor tRNA associated protein; UGA suppressor tRNA-associated protein;

Immunogens

Immunogen:

A synthesized peptide derived from human SEPSECS.

Uniprot:

Q9HD40(SPCS_HUMAN) >>Visit HPA database.

Gene(ID):
SEPSECS(51091)
Expression:
Q9HD40 SPCS_HUMAN:

Primarily expressed in liver, pancreas, kidney and lung. Overexpressed in PHA-stimulated T-cells.

Sequence:
MNRESFAAGERLVSPAYVRQGCEARRSHEHLIRLLLEKGKCPENGWDESTLELFLHELAIMDSNNFLGNCGVGEREGRVASALVARRHYRFIHGIGRSGDISAVQPKAAGSSLLNKITNSLVLDIIKLAGVHTVANCFVVPMATGMSLTLCFLTLRHKRPKAKYIIWPRIDQKSCFKSMITAGFEPVVIENVLEGDELRTDLKAVEAKVQELGPDCILCIHSTTSCFAPRVPDRLEELAVICANYDIPHIVNNAYGVQSSKCMHLIQQGARVGRIDAFVQSLDKNFMVPVGGAIIAGFNDSFIQEISKMYPGRASASPSLDVLITLLSLGSNGYKKLLKERKEMFSYLSNQIKKLSEAYNERLLHTPHNPISLAMTLKTLDEHRDKAVTQLGSMLFTRQVSGARVVPLGSMQTVSGYTFRGFMSHTNNYPCAYLNAASAIGMKMQDVDLFIKRLDRCLKAVRKERSKESDDNYDKTEDVDIEEMALKLDNVLLDTYQDASS

Research Backgrounds

Function:

Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.

Subcellular Location:

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Primarily expressed in liver, pancreas, kidney and lung. Overexpressed in PHA-stimulated T-cells.

Subunit Structure:

Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.

Family&Domains:

Belongs to the SepSecS family.

Research Fields

· Genetic Information Processing > Translation > Aminoacyl-tRNA biosynthesis.

· Metabolism > Metabolism of other amino acids > Selenocompound metabolism.

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