C15orf38 Antibody - #DF14443

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Product: C15orf38 Antibody
Catalog: DF14443
Description: Rabbit polyclonal antibody to C15orf38
Application: IHC IF/ICC
Reactivity: Human, Mouse
Mol.Wt.: 25kD(Calculated).
Uniprot: Q7Z6K5

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Clonality:
Polyclonal
Specificity:
C15orf38 Antibody detects endogenous levels of total C15orf38.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

2610034B18Rik; Actin related protein 2/3 complex inhibitor; Arp2/3 inhibition protein; ARPIN; C15orf38; Chromosome 15 open reading frame 38; CO038_HUMAN; Hypothetical protein LOC348110; MGC61550; RIKEN cDNA 2610034B18; UPF0552 protein C15orf38;

Immunogens

Immunogen:

A synthesized peptide derived from Human C15orf38.

Uniprot:

Q7Z6K5(ARPIN_HUMAN) >>Visit HPA database.

Gene(ID):
ARPIN(348110)
Sequence:
MSRIYHDGALRNKAVQSVRLPGAWDPAAHQGGNGVLLEGELIDVSRHSILDTHGRKERYYVLYIRPSHIHRRKFDAKGNEIEPNFSATRKVNTGFLMSSYKVEAKGDTDRLTPEALKGLVNKPELLALTESLTPDHTVAFWMPESEMEVMELELGAGVRLKTRGDGPFLDSLAKLEAGTVTKCNFTGDGKTGASWTDNIMAQKCSKGAAAEIREQGDGAEDEEWDD

Research Backgrounds

Function:

Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.

Subcellular Location:

Cell projection>Lamellipodium.
Note: Colocalized with the WAVE complex at lamelliupodium tip.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Associates with the Arp2/3 complex. Interacts with ARPC2; enhanced by activated RAC1. Interacts with ARPC5; the interaction is dependent on RAC1.

Family&Domains:

The acidic C-terminus is necessary and sufficient to inhibit ARP2/3 complex activity.

Belongs to the Arpin family.

Restrictive clause

 

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