ANTXR2 Antibody - #DF14434

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Product: ANTXR2 Antibody
Catalog: DF14434
Description: Rabbit polyclonal antibody to ANTXR2
Application: IHC IF/ICC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 50~70kD; 54kD(Calculated).
Uniprot: P58335

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 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
ANTXR2 Antibody detects endogenous levels of total ANTXR2.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

2310046B19Rik; Anthrax toxin receptor 2; ANTR2_HUMAN; Antxr2; AW561899; Capillary morphogenesis gene 2 protein; Capillary morphogenesis protein 2; CMG 2; CMG-2; CMG2; FLJ31074; HFS; ISH; JHF; MGC111533; MGC45856;

Immunogens

Immunogen:

A synthesized peptide derived from Human ANTXR2.

Uniprot:

P58335(ANTR2_HUMAN) >>Visit HPA database.

Gene(ID):
ANTXR2(118429)
Expression:
P58335 ANTR2_HUMAN:

Expressed in prostate, thymus, ovary, testis, pancreas, colon, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, skeletal muscle, small intestine and spleen.

Sequence:
MVAERSPARSPGSWLFPGLWLLVLSGPGGLLRAQEQPSCRRAFDLYFVLDKSGSVANNWIEIYNFVQQLAERFVSPEMRLSFIVFSSQATIILPLTGDRGKISKGLEDLKRVSPVGETYIHEGLKLANEQIQKAGGLKTSSIIIALTDGKLDGLVPSYAEKEAKISRSLGASVYCVGVLDFEQAQLERIADSKEQVFPVKGGFQALKGIINSILAQSCTEILELQPSSVCVGEEFQIVLSGRGFMLGSRNGSVLCTYTVNETYTTSVKPVSVQLNSMLCPAPILNKAGETLDVSVSFNGGKSVISGSLIVTATECSNGIAAIIVILVLLLLLGIGLMWWFWPLCCKVVIKDPPPPPAPAPKEEEEEPLPTKKWPTVDASYYGGRGVGGIKRMEVRWGDKGSTEEGARLEKAKNAVVKIPEETEEPIRPRPPRPKPTHQPPQTKWYTPIKGRLDALWALLRRQYDRVSLMRPQEGDEVCIWECIEKELTA

Research Backgrounds

Function:

Necessary for cellular interactions with laminin and the extracellular matrix.

Subcellular Location:

Cell membrane>Single-pass type I membrane protein.
Note: Expressed at the cell surface.

Endoplasmic reticulum membrane>Single-pass type I membrane protein.
Note: Expressed predominantly within the endoplasmic reticulum and not at the plasma membrane.

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in prostate, thymus, ovary, testis, pancreas, colon, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, skeletal muscle, small intestine and spleen.

Subunit Structure:

Binds laminin, and possibly also collagen type IV. Binds to the protective antigen (PA) of Bacillus anthracis in a divalent cation-dependent manner, with the following preference: calcium > manganese > magnesium > zinc. Binding of PA leads to heptamerization of the receptor-PA complex.

Family&Domains:

Binding to PA seems to be effected through the VWA domain.

Belongs to the ATR family.

Research Fields

· Organismal Systems > Immune system > NOD-like receptor signaling pathway.   (View pathway)

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