Centaurin alpha 1 Antibody - #DF14430

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Product: Centaurin alpha 1 Antibody
Catalog: DF14430
Description: Rabbit polyclonal antibody to Centaurin alpha 1
Application: WB IHC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 40-50kD; 43kD(Calculated).
Uniprot: O75689

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
Centaurin alpha 1 Antibody detects endogenous levels of total Centaurin alpha 1.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

ArfGAP with dual PH domains 1; CENTA 1; CENTA1; Centaurin alpha; GCS1L; p42IP4; Putative MAPK activating protein PM25;

Immunogens

Immunogen:

A synthesized peptide derived from Human Centaurin alpha 1.

Uniprot:

O75689(ADAP1_HUMAN) >>Visit HPA database.

Gene(ID):
ADAP1(11033)
Expression:
O75689 ADAP1_HUMAN:

Expressed at highest levels in brain and at lower levels in peripheral blood leukocytes.

Sequence:
MAKERRRAVLELLQRPGNARCADCGAPDPDWASYTLGVFICLSCSGIHRNIPQVSKVKSVRLDAWEEAQVEFMASHGNDAARARFESKVPSFYYRPTPSDCQLLREQWIRAKYERQEFIYPEKQEPYSAGYREGFLWKRGRDNGQFLSRKFVLTEREGALKYFNRNDAKEPKAVMKIEHLNATFQPAKIGHPHGLQVTYLKDNSTRNIFIYHEDGKEIVDWFNALRAARFHYLQVAFPGAGDADLVPKLSRNYLKEGYMEKTGPKQTEGFRKRWFTMDDRRLMYFKDPLDAFARGEVFIGSKESGYTVLHGFPPSTQGHHWPHGITIVTPDRKFLFACETESDQREWVAAFQKAVDRPMLPQEYAVEAHFKHKP

Research Backgrounds

Function:

GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).

PTMs:

Phosphorylated by PRKCA, PRKCI, PRKCZ and PRKD1 in vitro.

Subcellular Location:

Nucleus. Cytoplasm.
Note: Recruited to the plasma membrane upon epidermal growth factor-dependent activation of phosphatidylinositol 4,5-diphosphate (PtdInsP2) 3-kinase.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed at highest levels in brain and at lower levels in peripheral blood leukocytes.

Subunit Structure:

Interacts with PRKCA, PRKCI and PRKCZ. Interacts with the N-terminal region of PRKD1.

Restrictive clause

 

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