ALS2CR1 Antibody - #DF14350

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Product: ALS2CR1 Antibody
Catalog: DF14350
Description: Rabbit polyclonal antibody to ALS2CR1
Application: WB IHC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 37~45kD; 42kD(Calculated).
Uniprot: Q9GZT8

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IHC 1:50-1:200, WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
ALS2CR1 Antibody detects endogenous levels of total ALS2CR1.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

ALS2CR1; Amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 1; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 1 protein; CALS-7; MDS015; Ngg1 interacting factor 3-like 1; NIF3 (Ngg1 interacting factor 3, S.pombe homolog)-like 1; NIF3 NGG1 interacting factor 3-like 1 (S. pombe); NIF3 NGG1 interacting factor 3-like 1; NIF3-like protein 1; NIF3L_HUMAN; Nif3l1; OTTHUMP00000206190; OTTHUMP00000206191; OTTHUMP00000206192;

Immunogens

Immunogen:

A synthesized peptide derived from Human ALS2CR1.

Uniprot:

Q9GZT8(NIF3L_HUMAN) >>Visit HPA database.

Gene(ID):
NIF3L1(60491)
Sequence:
MLSSCVRPVPTTVRFVDSLICNSSRSFMDLKALLSSLNDFASLSFAESWDNVGLLVEPSPPHTVNTLFLTNDLTEEVMEEVLQKKADLILSYHPPIFRPMKRITWNTWKERLVIRALENRVGIYSPHTAYDAAPQGVNNWLAKGLGACTSRPIHPSKAPNYPTEGNHRVEFNVNYTQDLDKVMSAVKGIDGVSVTSFSARTGNEEQTRINLNCTQKALMQVVDFLSRNKQLYQKTEILSLEKPLLLHTGMGRLCTLDESVSLATMIDRIKRHLKLSHIRLALGVGRTLESQVKVVALCAGSGSSVLQGVEADLYLTGEMSHHDTLDAASQGINVILCEHSNTERGFLSDLRDMLDSHLENKINIILSETDRDPLQVV

Research Backgrounds

Function:

May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.

Subcellular Location:

Cytoplasm. Nucleus.
Note: Interaction with COPS2 may regulate localization to the nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Homodimer. Interacts with COPS2 (By similarity). Interacts with THOC7.

Family&Domains:

Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

Restrictive clause

 

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