CHST6 Antibody - #DF14345

(2)  
Product: CHST6 Antibody
Catalog: DF14345
Description: Rabbit polyclonal antibody to CHST6
Application: IHC IF/ICC
Reactivity: Human
Mol.Wt.: 44kD(Calculated).
Uniprot: Q9GZX3

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
CHST6 Antibody detects endogenous levels of total CHST6.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

C GlcNAc6ST; C-GlcNAc6ST; Carbohydate sulfotransferase 6; Carbohydrate (N acetylglucosamine 6 O) sulfotransferase 6; Carbohydrate sulfotransferase 6; CHST6; CHST6_HUMAN; Corneal GlcNAc6-sulfotransferase; Corneal N acetylglucosamine 6 sulfotransferase; Corneal N-acetylglucosamine-6-O-sulfotransferase; Galactose N acetylglucosamine N acetylglucosamine 6 O sulfotransferase 4 beta; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-beta; GlcNAc6ST 5; GlcNAc6ST-5; Gn6st-5; GST4 beta; GST4-beta; hCGn6ST; N-acetylglucosamine 6-O-sulfotransferase 5;

Immunogens

Immunogen:

A synthesized peptide derived from Human CHST6.

Uniprot:

Q9GZX3(CHST6_HUMAN) >>Visit HPA database.

Gene(ID):
CHST6(4166)
Expression:
Q9GZX3 CHST6_HUMAN:

Expressed in cornea. Mainly expressed in brain. Also expressed in spinal cord and trachea.

Sequence:
MWLPRVSSTAVTALLLAQTFLLLFLVSRPGPSSPAGGEARVHVLVLSSWRSGSSFVGQLFNQHPDVFYLMEPAWHVWTTLSQGSAATLHMAVRDLVRSVFLCDMDVFDAYLPWRRNLSDLFQWAVSRALCSPPACSAFPRGAISSEAVCKPLCARQSFTLAREACRSYSHVVLKEVRFFNLQVLYPLLSDPALNLRIVHLVRDPRAVLRSREQTAKALARDNGIVLGTNGTWVEADPGLRVVREVCRSHVRIAEAATLKPPPFLRGRYRLVRFEDLAREPLAEIRALYAFTGLSLTPQLEAWIHNITHGSGPGARREAFKTSSRNALNVSQAWRHALPFAKIRRVQELCAGALQLLGYRPVYSEDEQRNLALDLVLPRGLNGFTWASSTASHPRN

Research Backgrounds

Function:

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. Mediates sulfation of keratan in cornea. Keratan sulfate plays a central role in maintaining corneal transparency. Acts on the non-reducing terminal GlcNAc of short and long carbohydrate substrates that have poly-N-acetyllactosamine structures.

Subcellular Location:

Golgi apparatus membrane>Single-pass type II membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in cornea. Mainly expressed in brain. Also expressed in spinal cord and trachea.

Family&Domains:

Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.

Research Fields

· Metabolism > Glycan biosynthesis and metabolism > Glycosaminoglycan biosynthesis - keratan sulfate.

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