TP53INP2 Antibody - #DF14312

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Product: TP53INP2 Antibody
Catalog: DF14312
Description: Rabbit polyclonal antibody to TP53INP2
Application: WB IF/ICC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 24kD(Calculated).
Uniprot: Q8IXH6

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 100ul $280 In stock
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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
TP53INP2 Antibody detects endogenous levels of total TP53INP2.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

C20orf110; Diabetes and obesity regulated; p53 inducible protein U; DOR; p53-inducible protein U; PIG-U; PINH; T53I2_HUMAN; Tp53inp2; Tumor protein p53-inducible nuclear protein 2;

Immunogens

Immunogen:

A synthesized peptide derived from Human TP53INP2.

Uniprot:

Q8IXH6(T53I2_HUMAN) >>Visit HPA database.

Gene(ID):
TP53INP2(58476)
Sequence:
MFQRLSSLFFSTPSPPEDPDCPRAFVSEEDEVDGWLIIDLPDSYAAPPSPGAAPAPAGRPPPAPSLMDESWFVTPPACFTAEGPGLGPARLQSSPLEDLLIEHPSMSVYVTGSTIVLEPGSPSPLPDAALPDGDLSEGELTPARREPRAARHAAPLPARAALLEKAGQVRRLQRARQRAERHALSAKAVQRQNRARESRPRRSKNQSSFIYQPCQRQFNY

Research Backgrounds

Function:

Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.

Subcellular Location:

Cytoplasm>Cytosol. Nucleus. Nucleus>PML body. Cytoplasmic vesicle>Autophagosome.
Note: Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Interacts with VMP1, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, MAP1LC3C and THRA.

Family&Domains:

The LC3 interacting region (LIR) motif mediates interaction with GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B and MAP1LC3C.

Research Fields

· Cellular Processes > Transport and catabolism > Autophagy - animal.   (View pathway)

References

1). TP53INP2 knockdown inhibits inflammatory response and apoptosis after spinal cord injury. Immunity, inflammation and disease, 2024 (PubMed: 38652010) [IF=3.2]

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