SPINK2 Antibody - #DF14268

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Product: SPINK2 Antibody
Catalog: DF14268
Description: Rabbit polyclonal antibody to SPINK2
Application: IF/ICC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 9kD; 9kD(Calculated).
Uniprot: P20155

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 100ul $280 In stock
 200ul $350 In stock

Lead Time: Same day delivery

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
SPINK2 Antibody detects endogenous levels of total SPINK2.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Acrosin-trypsin inhibitor; HUSI-II; ISK2_HUMAN; Serine protease inhibitor Kazal-type 2; SPINK2;

Immunogens

Immunogen:

A synthesized peptide derived from Human SPINK2.

Uniprot:

P20155(ISK2_HUMAN) >>Visit HPA database.

Gene(ID):
SPINK2(6691)
Expression:
P20155 ISK2_HUMAN:

Expressed in epididymis (at protein level).

Sequence:
MALSVLRLALLLLAVTFAASLIPQFGLFSKYRTPNCSQYRLPGCPRHFNPVCGSDMSTYANECTLCMKIREGGHNIKIIRNGPC

Research Backgrounds

Function:

As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects. May be involved in the regulation of serine protease-dependent germ cell apoptosis (By similarity). It also inhibits trypsin.

Subcellular Location:

Secreted. Cytoplasmic vesicle>Secretory vesicle>Acrosome.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in epididymis (at protein level).

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