STXBP2 Antibody - #DF14196

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Product: STXBP2 Antibody
Catalog: DF14196
Description: Rabbit polyclonal antibody to STXBP2
Application: WB IF/ICC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 66kD; 66kD(Calculated).
Uniprot: Q15833

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
STXBP2 Antibody detects endogenous levels of total STXBP2.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

FHL5; Hunc18b; MUNC18 2; pp10122; Protein unc-18 homolog 2; Protein unc-18 homolog B; STXB2_HUMAN; Stxbp2; syntaxin binding protein 2; Syntaxin-binding protein 2; Unc-18B; UNC18 2; Unc18-2; UNC18B;

Immunogens

Immunogen:

A synthesized peptide derived from Human STXBP2.

Uniprot:

Q15833(STXB2_HUMAN) >>Visit HPA database.

Gene(ID):
STXBP2(6813)
Expression:
Q15833 STXB2_HUMAN:

Placenta, lung, liver, kidney and pancreas, as well as in peripheral blood lymphocytes.

Sequence:
MAPSGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSCCKMSDILAEGITIVEDINKRREPIPSLEAIYLLSPTEKSVQALIKDFQGTPTFTYKAAHIFFTDTCPEPLFSELGRSRLAKVVKTLKEIHLAFLPYEAQVFSLDAPHSTYNLYCPFRAEERTRQLEVLAQQIATLCATLQEYPAIRYRKGPEDTAQLAHAVLAKLNAFKADTPSLGEGPEKTRSQLLIMDRAADPVSPLLHELTFQAMAYDLLDIEQDTYRYETTGLSEAREKAVLLDEDDDLWVELRHMHIADVSKKVTELLRTFCESKRLTTDKANIKDLSQILKKMPQYQKELNKYSTHLHLADDCMKHFKGSVEKLCSVEQDLAMGSDAEGEKIKDSMKLIVPVLLDAAVPAYDKIRVLLLYILLRNGVSEENLAKLIQHANVQAHSSLIRNLEQLGGTVTNPGGSGTSSRLEPRERMEPTYQLSRWTPVIKDVMEDAVEDRLDRNLWPFVSDPAPTASSQAAVSARFGHWHKNKAGIEARAGPRLIVYVMGGVAMSEMRAAYEVTRATEGKWEVLIGSSHILTPTRFLDDLKALDKKLEDIALP

Research Backgrounds

Function:

Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells.

Tissue Specificity:

Placenta, lung, liver, kidney and pancreas, as well as in peripheral blood lymphocytes.

Subunit Structure:

Interacts with STX1A, STX2 and STX3 (By similarity). Interacts with STX11.

Family&Domains:

Belongs to the STXBP/unc-18/SEC1 family.

Restrictive clause

 

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